Anti-Shwachman Bodian-Diamond syndrome antibody [AT1E8] (ab156615)

Overview

  • Product name
    Anti-Shwachman Bodian-Diamond syndrome antibody [AT1E8]
    See all Shwachman Bodian-Diamond syndrome primary antibodies
  • Description
    Mouse monoclonal [AT1E8] to Shwachman Bodian-Diamond syndrome
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 1-250 of Human Shwachman Bodian-Diamond syndrome, purified from E. coli (NP_057122).

  • Positive control
    • HeLa cell lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage buffer
    pH: 7.40
    Preservative: 0.1% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Protein G purified
  • Clonality
    Monoclonal
  • Clone number
    AT1E8
  • Isotype
    IgG2b
  • Light chain type
    kappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab156615 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/3000. Predicted molecular weight: 29 kDa.
ELISA Use at an assay dependent dilution.

Target

  • Function
    Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.
  • Tissue specificity
    Widely expressed.
  • Involvement in disease
    Defects in SBDS are the cause of Shwachman-Diamond syndrome (SDS) [MIM:260400]. SDS is an autosomal recessive disorder characterized by pancreatic exocrine insufficiency, hematologic dysfunction, and skeletal abnormalities.
  • Sequence similarities
    Belongs to the SDO1/SBDS family.
  • Cellular localization
    Cytoplasm. Nucleus > nucleolus. Nucleus > nucleoplasm. Cytoplasm > cytoskeleton > spindle. Primarily detected in the cytoplasm, and at low levels in nucleus and nucleolus (PubMed:19602484 and PubMed:17475909). Detected in the nucleolus during G1 and G2 phase of the cell cycle, and diffusely distributed in the nucleus during S phase. Detected at the mitotic spindle. Colocalizes with the microtubule organizing center during interphase.
  • Information by UniProt
  • Database links
  • Alternative names
    • 4733401P19Rik antibody
    • AI836084 antibody
    • CGI 97 antibody
    • CGI-97 antibody
    • FLJ10917 antibody
    • MGC105922 antibody
    • Protein 22A3 antibody
    • Ribosome maturation protein SBDS antibody
    • sbds antibody
    • SBDS_HUMAN antibody
    • SDS antibody
    • Shwachman Bodian Diamond syndrome protein antibody
    • Shwachman Bodian Diamond syndrome protein homolog antibody
    • Shwachman-Bodian-Diamond syndrome protein antibody
    • SWDS antibody
    see all

Images

  • Anti-Shwachman Bodian-Diamond syndrome antibody [AT1E8] (ab156615) at 1/3000 dilution + HeLa cell lysate at 40 µg

    Secondary
    Goat anti-mouse HRP
    Developed using the ECL technique

    Predicted band size : 29 kDa

References

ab156615 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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