Overview

  • Product nameAnti-SI antibody [4C5G6]
    See all SI primary antibodies
  • Description
    Mouse monoclonal [4C5G6] to SI
  • Tested applicationsSuitable for: IPmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Normal human jejunal epithelial brush border-enriched membranes from a non-secretor and blood group O

  • General notesGrowth Conditions: RPMI 1640 + 20% FCS containing 10-6 M thymidine, 1.6x10-7 M hypoxanthine and 10-5 M methotrexate.


    ab105467 can be used for the detection of sucrase isomaltase in clinical material to test for loss of absorptive function/sucrose intolerance.

Properties

Applications

Our Abpromise guarantee covers the use of ab105467 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at an assay dependent dilution.

Target

  • FunctionPlays an important role in the final stage of carbohydrate digestion.
  • Tissue specificityExpressed in the poorly differentiated crypt cells of the small intestine as well as in the mature villous cells. Expressed at very low levels in the colon.
  • Involvement in diseaseDefects in SI are the cause of congenital sucrase-isomaltase deficiency (CSID) [MIM:222900]; also known as disaccharide intolerance I. CSID is an autosomal recessive intestinal disorder that is clinically characterized by fermentative diarrhea, abdominal pain, and cramps upon ingestion of sugar. The symptoms are the consequence of absent or drastically reduced enzymatic activities of sucrase and isomaltase. The prevalence of CSID is 0.02 % in individuals of European descent and appears to be much higher in Greenland, Alaskan, and Canadian native people. CSID arises due to post-translational perturbations in the intracellular transport, polarized sorting, aberrant processing, and defective function of SI.
  • Sequence similaritiesBelongs to the glycosyl hydrolase 31 family.
    Contains 2 P-type (trefoil) domains.
  • Post-translational
    modifications
    The precursor is proteolytically cleaved when exposed to pancreatic proteases in the intestinal lumen.
    Sulfated.
  • Cellular localizationApical cell membrane. Brush border.
  • Information by UniProt
  • Database links
  • FormSucrase-isomaltase is composed of 2 polypeptide chains of similar size linked together by noncovalent bonds. The polypeptide chains show a high degree of overlapping substrate specificity and are synthesized as 1 long polypeptide chain which, by means of pancreatic proteases, is later split into the 2 subunits.
  • Alternative names
    • Isomaltase antibody
    • MGC131621 antibody
    • MGC131622 antibody
    • Oligosaccharide alpha 1, 6 glucosidase antibody
    • SI antibody
    • sucrase isomaltase alpha glucosidase antibody
    • sucrase isomaltase antibody
    • Sucrase-isomaltase, intestinal antibody
    • SUIS_HUMAN antibody
    see all

References for Anti-SI antibody [4C5G6] (ab105467)

ab105467 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"