The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application notesWB: Use at a concentration of 1-5 µg/ml.
This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
FunctionPlays an important role in the final stage of carbohydrate digestion.
Tissue specificityExpressed in the poorly differentiated crypt cells of the small intestine as well as in the mature villous cells. Expressed at very low levels in the colon.
Involvement in diseaseDefects in SI are the cause of congenital sucrase-isomaltase deficiency (CSID) [MIM:222900]; also known as disaccharide intolerance I. CSID is an autosomal recessive intestinal disorder that is clinically characterized by fermentative diarrhea, abdominal pain, and cramps upon ingestion of sugar. The symptoms are the consequence of absent or drastically reduced enzymatic activities of sucrase and isomaltase. The prevalence of CSID is 0.02 % in individuals of European descent and appears to be much higher in Greenland, Alaskan, and Canadian native people. CSID arises due to post-translational perturbations in the intracellular transport, polarized sorting, aberrant processing, and defective function of SI.
Sequence similaritiesBelongs to the glycosyl hydrolase 31 family. Contains 2 P-type (trefoil) domains.
Post-translational modificationsThe precursor is proteolytically cleaved when exposed to pancreatic proteases in the intestinal lumen. Sulfated.
FormSucrase-isomaltase is composed of 2 polypeptide chains of similar size linked together by noncovalent bonds. The polypeptide chains show a high degree of overlapping substrate specificity and are synthesized as 1 long polypeptide chain which, by means of pancreatic proteases, is later split into the 2 subunits.
Oligosaccharide alpha 1, 6 glucosidase antibody
sucrase isomaltase alpha glucosidase antibody
sucrase isomaltase antibody
Sucrase-isomaltase, intestinal antibody
Anti-SI antibody images
Western blot - SI antibody (ab55738)
Western blot against tagged recombinant protein immunogen using ab55738 SI antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa
References for Anti-SI antibody (ab55738)
has not yet been referenced specifically in any publications.
Publishing research using ab55738? Please let us know so that we can cite the reference in this datasheet.
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