Anti-Siah2 antibody - Aminoterminal end (ab59473)

Overview

  • Product nameAnti-Siah2 antibody - Aminoterminal end
    See all Siah2 primary antibodies
  • Description
    Rabbit polyclonal to Siah2 - Aminoterminal end
  • Tested applicationsSuitable for: IHC-Fr, IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: a wide range of other species
  • Immunogen

    Synthetic peptide derived from N terminal region of human Siah2

Properties

Applications

Our Abpromise guarantee covers the use of ab59473 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr 1/500 - 1/2000.
IHC-P Use at an assay dependent concentration.
WB 1/500 - 1/2000. Predicted molecular weight: 36 kDa.

Target

  • FunctionE3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 can not. Promotes monoubiquitination of SNCA.
  • Tissue specificityWidely expressed at low level.
  • PathwayProtein modification; protein ubiquitination.
  • Sequence similaritiesBelongs to the SINA (Seven in absentia) family.
    Contains 1 RING-type zinc finger.
    Contains 1 SIAH-type zinc finger.
  • DomainThe RING-type zinc finger domain is essential for ubiquitin ligase activity.
    The SBD domain (substrate-binding domain) mediates the homodimerization and the interaction with substrate proteins. It is related to the TRAF family.
  • Cellular localizationCytoplasm. Nucleus. Predominantly cytoplasmic (Probable). Partially nuclear.
  • Information by UniProt
  • Database links
  • Alternative names
    • E3 ubiquitin-protein ligase Siah2 antibody
    • hSiah2 antibody
    • Seven in absentia homolog 2 antibody
    • Siah E3 ubiquitin protein ligase 2 antibody
    • Siah-2 antibody
    • siah2 antibody
    • SIAH2_HUMAN antibody
    • Ubiquitin Ligase Siah2 antibody
    see all

References for Anti-Siah2 antibody - Aminoterminal end (ab59473)

ab59473 has not yet been referenced specifically in any publications.

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