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Rabbit polyclonal to SIGIRR
Predicted to work with:
Mouse, Rat, Cow
Recombinant fragment corresponding to a region within amino acids 54 and 410 of Human SIGIRR (UniProt ID: Q6IA17).
A549, H1299, HCT116 or MCF7 whole cell lysate; Human gastric cancer tissue.
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Preservative: 0.01% Thimerosal (merthiolate) Constituents: 78% PBS, 20% Glycerol, 1% BSA
Concentration information loading...
Immunogen affinity purified
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/3000. Predicted molecular weight: 46 kDa.
1/100 - 1/1000.
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
Mainly expressed in epithelial tissues such as kidney, lung and gut.
Belongs to the interleukin-1 receptor family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 TIR domain.
Information by UniProt
Ig IL1 related receptor antibody
Western blot - Anti-SIGIRR antibody (ab154747)
All lanes : Anti-SIGIRR antibody (ab154747) at 1/3000 dilution Lane 1 : A549 whole cell lysate Lane 2 : H1299 whole cell lysate Lane 3 : HCT116 whole cell lysate Lane 4 : MCF7 whole cell lysate Lysates/proteins at 30 µg per lane. Predicted band size: 46 kDa 10% SDS PAGE
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SIGIRR antibody (ab154747)
Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue, labeling SIGIRR using ab154747 at 1/500 dilution.
has not yet been referenced specifically in any publications.
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