Overview

  • Product name
  • Description
    Rabbit polyclonal to SIGIRR
  • Tested applications
    Suitable for: WB, Flow Cytmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) Human.

  • Positive control
    • Human or mouse kidney cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab22053 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
Flow Cyt
  • Application notes
    Flow Cyt: Use 1µg for 106 cells.

    WB: Use at a concentration of 0.5 µg/ml. Detects a band of approximately 45 kDa in human kidney cell lysate, and a band of approximately 50 kDa in mouse kidney cell lysate.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
    • Tissue specificity
      Mainly expressed in epithelial tissues such as kidney, lung and gut.
    • Sequence similarities
      Belongs to the interleukin-1 receptor family.
      Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
      Contains 1 TIR domain.
    • Cellular localization
      Membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • Ig IL1 related receptor antibody
      • MGC110992 antibody
      • SIGIR_HUMAN antibody
      • SIGIRR antibody
      • Single Ig IL 1 related receptor antibody
      • Single Ig IL-1-related receptor antibody
      • Single Ig IL-1R-related molecule antibody
      • Single Ig IL1R Related Molecule antibody
      • Single immunoglobulin and toll interleukin 1 receptor (TIR) domain antibody
      • Single immunoglobulin and toll interleukin 1 receptor domain antibody
      • Single immunoglobulin domain containing IL1R related protein antibody
      • Single immunoglobulin domain IL1R1 related antibody
      • Single immunoglobulin domain-containing IL1R-related protein antibody
      • TIR 8 antibody
      • TIR8 antibody
      • Toll/interleukin 1 receptor 8 antibody
      • Toll/interleukin-1 receptor 8 antibody
      see all

    Images

    • All lanes : Anti-SIGIRR antibody (ab22053) at 0.5 µg/ml

      Lane 1 : human kidney cell lysate
      Lane 2 : mouse kidney cell lysate

      Lysates/proteins at 15 µg per lane.


      Observed band size : 45,50 kDa (why is the actual band size different from the predicted?)

    References

    This product has been referenced in:

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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