Overview

  • Product nameAnti-SIGIRR antibody
    See all SIGIRR primary antibodies
  • Description
    Rabbit polyclonal to SIGIRR
  • Tested applicationsSuitable for: WB, IHC-Frmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    A synthetic peptide corresponding to 15 amino acids at the carboxy terminus of mouse SIGIRR.

  • Positive control
    • A549 cell lysate

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: 0.02% Sodium Azide
    Constituents: PBS, pH 7.4
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesPurified IgG was prepared from whole serum by immunoaffinity chromatography.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab81516 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 43 kDa (predicted molecular weight: 46 kDa).
IHC-Fr Use a concentration of 10 µg/ml.

Target

  • FunctionActs as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
  • Tissue specificityMainly expressed in epithelial tissues such as kidney, lung and gut.
  • Sequence similaritiesBelongs to the interleukin-1 receptor family.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 TIR domain.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Ig IL1 related receptor antibody
    • MGC110992 antibody
    • SIGIR_HUMAN antibody
    • SIGIRR antibody
    • Single Ig IL 1 related receptor antibody
    • Single Ig IL-1-related receptor antibody
    • Single Ig IL-1R-related molecule antibody
    • Single Ig IL1R Related Molecule antibody
    • Single immunoglobulin and toll interleukin 1 receptor (TIR) domain antibody
    • Single immunoglobulin and toll interleukin 1 receptor domain antibody
    • Single immunoglobulin domain containing IL1R related protein antibody
    • Single immunoglobulin domain IL1R1 related antibody
    • Single immunoglobulin domain-containing IL1R-related protein antibody
    • TIR 8 antibody
    • TIR8 antibody
    • Toll/interleukin 1 receptor 8 antibody
    • Toll/interleukin-1 receptor 8 antibody
    see all

References for Anti-SIGIRR antibody (ab81516)

ab81516 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"