Anti-SIGIRR antibody [MM0547-10D5] (ab90253)

Overview

  • Product name
    Anti-SIGIRR antibody [MM0547-10D5]
    See all SIGIRR primary antibodies
  • Description
    Mouse monoclonal [MM0547-10D5] to SIGIRR
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Human recombinant SIGIRR extracellular domain

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: None
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Protein G purified
  • Purification notes
    The IgG fraction of culture supernatant was purified by protein G affinity chromatography and filtered through a 0.2 µm filter.
  • Clonality
    Monoclonal
  • Clone number
    MM0547-10D5
  • Isotype
    IgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab90253 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 46 kDa.

Target

  • Function
    Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
  • Tissue specificity
    Mainly expressed in epithelial tissues such as kidney, lung and gut.
  • Sequence similarities
    Belongs to the interleukin-1 receptor family.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 TIR domain.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Ig IL1 related receptor antibody
    • MGC110992 antibody
    • SIGIR_HUMAN antibody
    • SIGIRR antibody
    • Single Ig IL 1 related receptor antibody
    • Single Ig IL-1-related receptor antibody
    • Single Ig IL-1R-related molecule antibody
    • Single Ig IL1R Related Molecule antibody
    • Single immunoglobulin and toll interleukin 1 receptor (TIR) domain antibody
    • Single immunoglobulin and toll interleukin 1 receptor domain antibody
    • Single immunoglobulin domain containing IL1R related protein antibody
    • Single immunoglobulin domain IL1R1 related antibody
    • Single immunoglobulin domain-containing IL1R-related protein antibody
    • TIR 8 antibody
    • TIR8 antibody
    • Toll/interleukin 1 receptor 8 antibody
    • Toll/interleukin-1 receptor 8 antibody
    see all

References

ab90253 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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