Overview

  • Product nameAnti-Siglec 7 antibody
    See all Siglec 7 primary antibodies
  • Description
    Rabbit polyclonal to Siglec 7
  • Tested applicationsSuitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 191-427 of Human Siglec 7 (NP_055200).

  • Positive control
    • 293T, A431, Jurkat and Raji cells and whole cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab111619 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 51 kDa.
ICC/IF 1/100 - 1/500.

Target

  • FunctionPutative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
  • Tissue specificityPredominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes.
  • Sequence similaritiesBelongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • DomainContains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Post-translational
    modifications
    Tyrosine phosphorylated.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Adhesion inhibitory receptor molecule 1 antibody
    • Adhesion inhibitory receptor molecule 1, siglec 7 antibody
    • AIRM 1 antibody
    • AIRM-1 antibody
    • AIRM1 antibody
    • CD328 antibody
    • CD328 antigen antibody
    • CDw328 antibody
    • D siglec antibody
    • D-siglec antibody
    • HLDA 8 antibody
    • p75 antibody
    • p75/AIRM1 antibody
    • QA79 antibody
    • QA79 membrane protein antibody
    • Sialic acid binding Ig like lectin 7 antibody
    • Sialic acid binding immunoglobulin like lectin 7 antibody
    • Sialic acid-binding Ig-like lectin 7 antibody
    • SIGL7_HUMAN antibody
    • Siglec-7 antibody
    • SIGLEC19P antibody
    • SIGLEC7 antibody
    • SIGLECP2 antibody
    see all

Anti-Siglec 7 antibody images

  • Anti-Siglec 7 antibody (ab111619) at 1/1000 dilution + Jurkat whole cell lysate at 30 µg

    Predicted band size : 51 kDa
  • ab111619 at 1/200 dilution staining Siglec 7 in methanol-fixed A431 cells by Immunofluorescence. Lower image shows cells co-stained with Hoechst 33342.

References for Anti-Siglec 7 antibody (ab111619)

ab111619 has not yet been referenced specifically in any publications.

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