Anti-Siglec 7 antibody [MM0551-8D8] (ab89483)


  • Product nameAnti-Siglec 7 antibody [MM0551-8D8]
    See all Siglec 7 primary antibodies
  • Description
    Mouse monoclonal [MM0551-8D8] to Siglec 7
  • Specificityab89483 cross reacts with Siglec 14.
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment of Human Siglec 7 extracellular domain.



Our Abpromise guarantee covers the use of ab89483 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesIHC-P: 1/20 - 1/200.
    WB: 1/500 - 1/1000. Predicted molecular weight: 51 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionPutative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
    • Tissue specificityPredominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes.
    • Sequence similaritiesBelongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
      Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
      Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    • DomainContains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
    • Post-translational
      Tyrosine phosphorylated.
    • Cellular localizationMembrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • Adhesion inhibitory receptor molecule 1 antibody
      • Adhesion inhibitory receptor molecule 1, siglec 7 antibody
      • AIRM 1 antibody
      • AIRM-1 antibody
      • AIRM1 antibody
      • CD328 antibody
      • CD328 antigen antibody
      • CDw328 antibody
      • D siglec antibody
      • D-siglec antibody
      • HLDA 8 antibody
      • p75 antibody
      • p75/AIRM1 antibody
      • QA79 antibody
      • QA79 membrane protein antibody
      • Sialic acid binding Ig like lectin 7 antibody
      • Sialic acid binding immunoglobulin like lectin 7 antibody
      • Sialic acid-binding Ig-like lectin 7 antibody
      • SIGL7_HUMAN antibody
      • Siglec-7 antibody
      • SIGLEC19P antibody
      • SIGLEC7 antibody
      • SIGLECP2 antibody
      see all

    References for Anti-Siglec 7 antibody [MM0551-8D8] (ab89483)

    ab89483 has not yet been referenced specifically in any publications.

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