Overview

  • Product name
  • Description
    Rabbit polyclonal to SIGLEC10
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A KLH conjugated synthetic peptide selected from the C-terminal region of Human SIGLEC10.

  • Positive control
    • HeLa Cell Lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    This antibody is purified through a protein A column, followed by peptide affinity purification.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab112564 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 77 kDa.

Target

  • Function
    Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
  • Tissue specificity
    Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation). Isoform 5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow, spleen and spinal chord. Isoform 2 is also found in brain. Isoform 4 is specifically found in natural killer cells.
  • Sequence similarities
    Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
    Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Domain
    Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Post-translational
    modifications
    Phosphorylation of Tyr-667 is involved in binding to PTPN6.
  • Cellular localization
    Secreted and Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • mSiglec G antibody
    • PRO940 antibody
    • Sialic acid binding Ig like lectin 10 antibody
    • Sialic acid binding Ig like lectin 10 antibody
    • sialic acid binding Ig like lectin 10 Ig like lectin 7 antibody
    • sialic acid binding Ig like lectin G antibody
    • Sialic acid binding Immunoglobulin like lectin 10 antibody
    • Sialic acid-binding Ig-like lectin 10 antibody
    • SIG10_HUMAN antibody
    • SIGLEC 10 antibody
    • Siglec G antibody
    • siglec like gene 2 antibody
    • Siglec like protein 2 antibody
    • Siglec like protein 2 antibody
    • Siglec-10 antibody
    • Siglec-like protein 2 antibody
    • SIGLEC10 antibody
    • Siglecg antibody
    • SLG2 antibody
    see all

Images

  • Anti-SIGLEC10 antibody (ab112564) at 1/100 dilution + HeLa Cell Lysate at 35 µg

    Predicted band size : 77 kDa

References

ab112564 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab112564.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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