Overview

  • Product nameAnti-SIGLEC11 antibody
    See all SIGLEC11 primary antibodies
  • Description
    Rabbit polyclonal to SIGLEC11
  • SpecificitySpecific to Human SIGLEC11, does not cross react with SIGLEC10.
  • Tested applicationsSuitable for: ICC/IF, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    18 amino acid peptide from near the carboxy terminus of Human SIGLEC11 (NP_443116).

  • Positive control
    • HepG2 cell lysate Human liver tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab106390 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 76 kDa.
IHC-P Use a concentration of 5 µg/ml.

Target

  • FunctionPutative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
  • Tissue specificityExpressed by macrophages in various tissues including Kupffer cells. Also found in brain microglia.
  • Sequence similaritiesBelongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
    Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • DomainContains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Post-translational
    modifications
    Phosphorylated on tyrosine residues.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • sialic acid binding Ig like lectin 11 antibody
    • sialic acid binding lectin 11 antibody
    • Sialic acid-binding Ig-like lectin 11 antibody
    • Sialic acid-binding lectin 11 antibody
    • SIG11_HUMAN antibody
    • Siglec 11 antibody
    • Siglec-11 antibody
    • SIGLEC11 antibody
    see all

Anti-SIGLEC11 antibody images

  • Immunofluorescence of SIGLEC11 in Human liver tissue with ab106390 at 20 ug/mL.

  • Anti-SIGLEC11 antibody (ab106390) at 1 µg/ml + HepG2 cell lysate at 15 µg

    Predicted band size : 76 kDa
  • ab106390 at 5µg/ml, staining SIGLEC11 in Human liver, using Immunohistochemistry, Formalin/PFA-fixed paraffin-embedded tissue.

References for Anti-SIGLEC11 antibody (ab106390)

ab106390 has not yet been referenced specifically in any publications.

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