Overview

  • Product nameAnti-SIGLEC11 antibody
    See all SIGLEC11 primary antibodies
  • Description
    Rabbit polyclonal to SIGLEC11
  • Tested applicationsSuitable for: ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide (10-30 aa in length) from the C-terminus of human SIGLEC11, conjugated to KLH.

  • Positive control
    • Human hepatocarcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab59944 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1000.
IHC-P 1/50 - 1/100.

Target

  • FunctionPutative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
  • Tissue specificityExpressed by macrophages in various tissues including Kupffer cells. Also found in brain microglia.
  • Sequence similaritiesBelongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
    Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • DomainContains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Post-translational
    modifications
    Phosphorylated on tyrosine residues.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • sialic acid binding Ig like lectin 11 antibody
    • sialic acid binding lectin 11 antibody
    • Sialic acid-binding Ig-like lectin 11 antibody
    • Sialic acid-binding lectin 11 antibody
    • SIG11_HUMAN antibody
    • Siglec 11 antibody
    • Siglec-11 antibody
    • SIGLEC11 antibody
    see all

Anti-SIGLEC11 antibody images

  • ab59944 at 1/50 - 1/100 dilution, staining SIGLEC11 in human hepatocarcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue, followed by peroxidase-conjugated secondary antibody and AEC staining.

References for Anti-SIGLEC11 antibody (ab59944)

ab59944 has not yet been referenced specifically in any publications.

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