Overview

  • Product nameAnti-SIGLEC5 antibody
    See all SIGLEC5 primary antibodies
  • Description
    Rabbit polyclonal to SIGLEC5
  • Tested applicationsSuitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide (10-30 aa in length) at the C-term of last 50 aa of human SIGLEC5 conjugated to KLH

  • Positive control
    • Mouse liver tissue

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage bufferPreservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab38582 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 61 kDa (predicted molecular weight: 61 kDa).

Target

  • FunctionPutative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
  • Tissue specificityExpressed by monocytic/myeloid lineage cells. Found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. Expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation.
  • Sequence similaritiesBelongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • DomainContains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD170 antibody
    • CD170 antigen antibody
    • CD33 antigen-like 2 antibody
    • CD33L2 antibody
    • mSiglec-F antibody
    • OB-binding protein 2 antibody
    • OB-BP2 antibody
    • OBBP2 antibody
    • Obesity-binding protein 2 antibody
    • Sialic acid binding Ig-like lectin 5 antibody
    • Sialic acid binding immunoglobulin-like lectin 5 antibody
    • Sialic acid-binding Ig-like lectin 5 antibody
    • Sialic acid-binding Ig-like lectin F antibody
    • SIGL5_HUMAN antibody
    • Siglec-5 antibody
    • Siglec-F variant antibody
    • Siglec5 antibody
    • Siglecf antibody
    see all

Anti-SIGLEC5 antibody images

  • Anti-SIGLEC5 antibody (ab38582) at 1/100 dilution + Mouse liver tissue lysate

    Predicted band size : 61 kDa
    Observed band size : 61 kDa
    Additional bands at : 41 kDa,75 kDa. We are unsure as to the identity of these extra bands.

References for Anti-SIGLEC5 antibody (ab38582)

ab38582 has not yet been referenced specifically in any publications.

Product Wall

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"