Overview

  • Product nameAnti-SIGLEC6 antibody
    See all SIGLEC6 primary antibodies
  • Description
    Goat polyclonal to SIGLEC6
  • Specificityab104930 is expected to recognize all reported isoforms (NP_001236.4; NP_942142.3; NP_942143.3).
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 126-136 (

    KWMKYGYTSSK

    ) of Human SIGLEC6 (NP_001236.4; NP_942142.3; NP_942143.3)

  • Positive control
    • Human placenta lysate.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesPurified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab104930 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 1.5 µg/ml. Predicted molecular weight: 50 kDa. Experiments gave bands at approx 60kDa and 35kDa in Human Placenta lysates. These bands correspond to earlier findings with different antibodies from other commercial sources.

Target

  • FunctionPutative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
  • Tissue specificityExpressed at high levels in placenta (cyto- and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine.
  • Sequence similaritiesBelongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • DomainContains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Cellular localizationSecreted and Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD327 antibody
    • CD33 antigen-like 1 antibody
    • CD33L antibody
    • CD33L1 antibody
    • CD33L2 antibody
    • CDw327 antibody
    • OB-BP1 antibody
    • OBBP1 antibody
    • Obesity-binding protein 1 antibody
    • Sialic acid-binding Ig-like lectin 6 antibody
    • SIGL6_HUMAN antibody
    • Siglec-6 antibody
    • SIGLEC6 antibody
    see all

Anti-SIGLEC6 antibody images

  • Anti-SIGLEC6 antibody (ab104930) at 0.5 µg/ml + Human placenta lysate in RIPA buffer at 35 µg

    Predicted band size : 50 kDa

References for Anti-SIGLEC6 antibody (ab104930)

ab104930 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab104930.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"