Overview

  • Product name
  • Description
    Goat polyclonal to SIGLEC6
  • Specificity
    ab104930 is expected to recognize all reported isoforms (NP_001236.4; NP_942142.3; NP_942143.3).
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 126-136 (

    KWMKYGYTSSK

    ) of Human SIGLEC6 (NP_001236.4; NP_942142.3; NP_942143.3)

  • Positive control
    • Human placenta lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab104930 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 1.5 µg/ml. Predicted molecular weight: 50 kDa. Experiments gave bands at approx 60kDa and 35kDa in Human Placenta lysates. These bands correspond to earlier findings with different antibodies from other commercial sources.

Target

  • Function
    Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
  • Tissue specificity
    Expressed at high levels in placenta (cyto- and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine.
  • Sequence similarities
    Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Domain
    Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Cellular localization
    Secreted and Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD327 antibody
    • CD33 antigen-like 1 antibody
    • CD33L antibody
    • CD33L1 antibody
    • CD33L2 antibody
    • CDw327 antibody
    • OB-BP1 antibody
    • OBBP1 antibody
    • Obesity-binding protein 1 antibody
    • Sialic acid-binding Ig-like lectin 6 antibody
    • SIGL6_HUMAN antibody
    • Siglec-6 antibody
    • SIGLEC6 antibody
    see all

Anti-SIGLEC6 antibody images

  • Anti-SIGLEC6 antibody (ab104930) at 0.5 µg/ml + Human placenta lysate in RIPA buffer at 35 µg

    Predicted band size : 50 kDa

References for Anti-SIGLEC6 antibody (ab104930)

ab104930 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab104930.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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