Overview

  • Product name
    Anti-SIGLEC8 antibody [7C9]
    See all SIGLEC8 primary antibodies
  • Description
    Mouse monoclonal [7C9] to SIGLEC8
  • Tested applications
    Suitable for: ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Siglec-8-Fc protein, containing entire extracellular region of Human Siglec-8 fused with the Fc region of human IgG1.

  • Positive control
    • Siglec-8 CHO cells vs non-transfected CHO cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab103398 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.

Target

  • Function
    Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
  • Tissue specificity
    Expressed specifically on eosinophils.
  • Sequence similarities
    Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Domain
    Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD329 antigen antibody
    • CDw329 antibody
    • SAF 2 antibody
    • SAF-2 antibody
    • SAF2 antibody
    • Sialic acid binding Ig like lectin 8 antibody
    • Sialic acid-binding Ig-like lectin 8 antibody
    • Sialoadhesin family member 2 antibody
    • SIGL8_HUMAN antibody
    • Siglec 8 antibody
    • Siglec-8 antibody
    • SIGLEC8 antibody
    • SIGLEC8L antibody
    see all

References

ab103398 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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