Overview

  • Product name
  • Description
    Goat polyclonal to SIGLEC8
  • Tested applications
    Suitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide:

    C-SYKSQLNYKTKQ

    , corresponding to internal sequence amino acids 134-145 of Human SIGLEC8 (NP_055257.2)

  • Positive control
    • MOLT4 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab79285 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
WB
  • Application notes
    Peptide ELISA: Antibody detection limit dilution 1/32000.
    WB: Use at a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 45 kDa (predicted molecular weight: 54 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
    • Tissue specificity
      Expressed specifically on eosinophils.
    • Sequence similarities
      Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
      Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
      Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    • Domain
      Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
    • Cellular localization
      Membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • CD329 antigen antibody
      • CDw329 antibody
      • SAF 2 antibody
      • SAF-2 antibody
      • SAF2 antibody
      • Sialic acid binding Ig like lectin 8 antibody
      • Sialic acid-binding Ig-like lectin 8 antibody
      • Sialoadhesin family member 2 antibody
      • SIGL8_HUMAN antibody
      • Siglec 8 antibody
      • Siglec-8 antibody
      • SIGLEC8 antibody
      • SIGLEC8L antibody
      see all

    Images

    References

    ab79285 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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