Anti-SIGLECL1 antibody - C-terminal (ab172940)

Overview

  • Product name
    Anti-SIGLECL1 antibody - C-terminal
    See all SIGLECL1 primary antibodies
  • Description
    Rabbit polyclonal to SIGLECL1 - C-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide within Human SIGLECL1 aa 566-595 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: Q96PQ1

  • Positive control
    • mouse bladder tissue lysate, Human spleen tissue.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Ammonium Sulphate Precipitation
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab172940 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/50 - 1/100. Predicted molecular weight: 65 kDa.

Target

  • Function
    Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
  • Tissue specificity
    Isoform Short is highly expressed in spleen, small intestine and adrenal gland; it is lower expressed in thyroid, placenta, brain, stomach, bone marrow, spinal chord and breast. Isoform Long is highly expressed in spleen, small intestine and bone marrow; it is lower expressed in thyroid, placenta, thymus, trachea, stomach, lung, adrenal gland, fetal brain and testis.
  • Sequence similarities
    Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 2 Ig-like V-type (immunoglobulin-like) domains.
  • Domain
    Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ38600 antibody
    • S2V antibody
    • sialic acid binding Ig-like lectin 12 (gene/pseudogene) antibody
    • Sialic acid-binding Ig-like lectin 12 antibody
    • Sialic acid-binding Ig-like lectin-like 1 antibody
    • Sialic acid-binding immunoglobulin-like lectins antibody
    • SIG12_HUMAN antibody
    • Siglec-12 antibody
    • Siglec-L1 antibody
    • SIGLEC-like 1 antibody
    • SIGLEC-like gene antibody
    • SIGLEC-like protein 1 antibody
    • Siglec-XII antibody
    • Siglec12 antibody
    • SLG antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed paraffin-embedded Human spleen tissue, labeling SIGLECL1 using ab172940 at a 1/50 dilution, followed by peroxidase conjugation of the secondary antibody and DAB staining.

  • Anti-SIGLECL1 antibody - C-terminal (ab172940) at 1/50 dilution + mouse bladder tissue lysate at 35 µg

    Predicted band size: 65 kDa

References

ab172940 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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