Anti-Signal Peptide Peptidase antibody (ab113872)

Overview

  • Product nameAnti-Signal Peptide Peptidase antibody
    See all Signal Peptide Peptidase primary antibodies
  • Description
    Rabbit polyclonal to Signal Peptide Peptidase
  • Specificityab113872 will recognise isoform 1, 3 and 4 UniProt ID Q9D8V0
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 240-289 (IKLVFPQDLL EKGLEADNFA MLGLGDIVIP GIFIALLLRF DISLKKNTHT) of Mouse Signal Peptide Peptidase (Q9D8V0 isoform 1).

  • Positive control
    • Mouse Spleen lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab113872 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 41 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionCatalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May play a role in graft rejection (By similarity). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1.
  • Tissue specificityWidely expressed with highest levels in kidney, liver, placenta, lung, leukocytes and small intestine and reduced expression in heart and skeletal muscle. Expressed abundantly in the CNS with highest levels in thalamus and medulla.
  • Sequence similaritiesBelongs to the peptidase A22B family.
  • Post-translational
    modifications
    N-glycosylated.
  • Cellular localizationCell membrane and Endoplasmic reticulum membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • dJ324O17.1 antibody
    • H13 antibody
    • hIMP1 antibody
    • Histocompatibility (minor) 13 antibody
    • HM13 antibody
    • HM13_HUMAN antibody
    • IMP-1 antibody
    • IMP1 antibody
    • IMPAS antibody
    • IMPAS-1 antibody
    • Intramembrane protease 1 antibody
    • Intramembrane protease antibody
    • Minor histocompatibility antigen 13 antibody
    • Minor histocompatibility antigen H13 antibody
    • MSTP086 antibody
    • OTTHUMP00000030527 antibody
    • OTTHUMP00000030528 antibody
    • OTTHUMP00000030530 antibody
    • OTTHUMP00000214528 antibody
    • Presenilin-like protein 3 antibody
    • PSENL3 antibody
    • PSL3 antibody
    • Signal peptide peptidase antibody
    • Signal peptide peptidase beta antibody
    • SPP antibody
    see all

Anti-Signal Peptide Peptidase antibody images

  • Anti-Signal Peptide Peptidase antibody (ab113872) at 1 µg/ml + Mouse spleen lysate at 10 µg

    Predicted band size : 41 kDa

References for Anti-Signal Peptide Peptidase antibody (ab113872)

ab113872 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab113872.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"