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Function
Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5.
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Tissue specificity
Highly expressed in tissues which produce large amounts of secreted proteins such as kidney, liver and placenta. Also expressed in colon, heart, lung, ovary, pancreas, peripheral leukocyte, prostate, spleen and thymus. Expressed at low levels throughout the brain.
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Involvement in disease
Defects in SIL1 are a cause of Marinesco-Sjoegren syndrome (MSS) [MIM:248800]. MSS is an autosomal recessive multisystem disorder which is characterized by cerebellar ataxia due to cerebellar atrophy, with Purkinje and granule cell loss and myopathy featuring marked muscle replacement with fat and connective tissue. Other cardinal features include bilateral cataracts, hypergonadotrophic hypogonadism and mild to severe mental retardation. Skeletal abnormalities, short stature, dysarthria, strabismus and nystagmus are also frequent findings. Mutational inactivation of this protein may result in ER stress-induced cell death signaling or malfunctioning chaperone machineries that mishandle client proteins which are critical for the organs targeted in MSS.
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Sequence similarities
Belongs to the SIL1 family.
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Developmental stage
Expressed in fetal kidney, fetal lung, fetal liver and at low levels in fetal brain.
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Post-translational
modifications
N-glycosylated.
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Cellular localization
Endoplasmic reticulum lumen.
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Information by UniProt
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Database links
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Alternative names
- BAP antibody
- BiP associated protein antibody
- BiP-associated protein antibody
- Endoplasmic reticulum chaperone SIL 1 antibody
- Endoplasmic reticulum chaperone SIL1 antibody
- MSS antibody
- Nucleotide exchange factor SIL 1 antibody
- Nucleotide exchange factor SIL1 antibody
- SIL 1 antibody
- sil1 antibody
- SIL1 homolog antibody
- SIL1 homolog endoplasmic reticulum chaperone (S. cerevisiae) antibody
- SIL1 homolog endoplasmic reticulum chaperone antibody
- SIL1_HUMAN antibody
- UGL 5 antibody
- ULG5 antibody
see all