Anti-SIL1 antibody (ab115554)

Overview

• Product name
  Anti-SIL1 antibody
  See all SIL1 primary antibodies
• Description
  Goat polyclonal to SIL1
• Tested applications
  Suitable for: ELISA, WB, IHC-Pmore details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic peptide:

  ELLGSVNSLLKELR

  with a Cysteine residue linker, corresponding to C terminal amino acids 448-461 of Human SIL1.

  Run BLAST with Run BLAST with
• Positive control
  • Human Kidney lysate; Human Liver and Testis tissues.

Properties

• Form
  Liquid
• Storage instructions
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• Storage buffer
  pH: 7.30
  Preservative: 0.02% Sodium azide
  Constituents: 99% Tris buffered saline, 0.5% BSA
• Concentration information loading...
• Purity
  Protein G purified
• Clonality
  Polyclonal
• Isotype
  IgG
• Research areas
  • Signal Transduction
  • Protein Trafficking
  • Chaperones
  • Heat Shock Proteins

  • Signal Transduction
  • Protein Trafficking
  • ER Proteins

  • Signal Transduction
  • Protein Trafficking
  • Chaperones
  • Other Chaperones

Associated products

• Compatible Secondaries
  • Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (ab150129)
  • Donkey Anti-Goat IgG H&L (HRP) (ab205723)

Applications

Target

• Function
  Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5.
• Tissue specificity
  Highly expressed in tissues which produce large amounts of secreted proteins such as kidney, liver and placenta. Also expressed in colon, heart, lung, ovary, pancreas, peripheral leukocyte, prostate, spleen and thymus. Expressed at low levels throughout the brain.
• Involvement in disease
  Defects in SIL1 are a cause of Marinesco-Sjoegren syndrome (MSS) [MIM:248800]. MSS is an autosomal recessive multisystem disorder which is characterized by cerebellar ataxia due to cerebellar atrophy, with Purkinje and granule cell loss and myopathy featuring marked muscle replacement with fat and connective tissue. Other cardinal features include bilateral cataracts, hypergonadotrophic hypogonadism and mild to severe mental retardation. Skeletal abnormalities, short stature, dysarthria, strabismus and nystagmus are also frequent findings. Mutational inactivation of this protein may result in ER stress-induced cell death signaling or malfunctioning chaperone machineries that mishandle client proteins which are critical for the organs targeted in MSS.
• Sequence similarities
  Belongs to the SIL1 family.
• Developmental stage
  Expressed in fetal kidney, fetal lung, fetal liver and at low levels in fetal brain.
• Post-translational
  modifications
  N-glycosylated.
• Cellular localization
  Endoplasmic reticulum lumen.

• Target information above from: UniProt accession Q9H173 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 64374 Human
  • Omim: 608005 Human
  • SwissProt: Q9H173 Human
  • Unigene: 483521 Human
• Alternative names
  • BAP antibody
  • BiP associated protein antibody
  • BiP-associated protein antibody

  • Endoplasmic reticulum chaperone SIL 1 antibody
  • Endoplasmic reticulum chaperone SIL1 antibody
  • MSS antibody
  • Nucleotide exchange factor SIL 1 antibody
  • Nucleotide exchange factor SIL1 antibody
  • SIL 1 antibody
  • sil1 antibody
  • SIL1 homolog antibody
  • SIL1 homolog endoplasmic reticulum chaperone (S. cerevisiae) antibody
  • SIL1 homolog endoplasmic reticulum chaperone antibody
  • SIL1_HUMAN antibody
  • UGL 5 antibody
  • ULG5 antibody

  see all

Protocols

• Western blot protocols
• Immunohistochemistry protocols