Overview

  • Product name
  • Description
    Rabbit polyclonal to Sin3b
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 165-325 of Human Sin3b.

  • Positive control
    • HCT116 whole cell lysate and MCF7 xenograft tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab101841 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 133 kDa.
IHC-P 1/100 - 1/500.

Target

  • Relevance
    Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription.
  • Cellular localization
    Nuclear
  • Database links
  • Alternative names
    • Histone deacetylase complex subunit Sin3b antibody
    • Paired amphipathic helix protein Sin3b antibody
    • SIN3 homolog B transcription regulator antibody
    • SIN3 transcription regulator family member B antibody
    • SIN3 transcription regulator homolog B antibody
    • Transcriptional corepressor Sin3b antibody
    see all

Images

  • Anti-Sin3b antibody (ab101841) at 1/500 dilution + HCT116 whole cell lysate at 30 µg

    Predicted band size : 133 kDa
  • Immunohistochemical analysis of Sin3b in paraffin embedded MCF7 xenograft, using ab101841 at a 1/100 dilution.

References

ab101841 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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