Overview

  • Product name
  • Description
    Rabbit polyclonal to SIPA1L1
  • Tested applications
    Suitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Rat, Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide conjugated to KLH, from the N terminal region of Human SIPA1L1

  • Positive control
    • Human kidney tissue; Rat brain tissue lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab113815 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 200 kDa.
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 10 µg/ml.

Target

  • Relevance
    SIPA1L1 (Signal-induced proliferation associated-like protein 1) is a member of the SIPA1 family of RapGAPs. SIPA1L1 was initially identified as a binding partner and degradation target of the E6 oncoprotein of high-risk papillomaviruses. Recently, it was discovered that Casein kinase I epsilon (CKIe), a Wnt-regulated kinase that regulates Wnt/b-catenin signaling, also can bind to the carboxy-terminus of SIPA1L1. CKIe phosphorylates SIPA1L1, thereby reducing its stability and alleviating its inhibition of Rap1, a protein required for Wnt8/CKIe-mediated gastrulation during embryogenesis, suggesting SIPA1L1 plays important roles in embryo development as well as control of cell proliferation.
  • Cellular localization
    Intracellular
  • Database links
  • Alternative names
    • DKFZp686G1344 antibody
    • E6 targeted protein 1 antibody
    • E6TP1 antibody
    • H_DJ1140G11.1 antibody
    • High risk human papilloma viruses E6 oncoproteins targeted protein 1 antibody
    • KIAA0440 antibody
    • Signal induced proliferation associated 1 like 1 antibody
    • Signal induced proliferation associated 1 like protein 1 antibody
    • SIPA1 like protein 1 antibody
    • WUGSC:H_DJ1140G11.1 antibody
    see all

Images

  • Lane 1 : Anti-SIPA1L1 antibody (ab113815) at 0.5 µg/ml
    Lane 2 : Anti-SIPA1L1 antibody (ab113815) at 1 µg/ml

    Lane 1 : Rat brain tissue lysate
    Lane 2 : Rat brain tissue lysate


    Predicted band size : 200 kDa
  • ab113815 at 10ug/ml staining SIPA1L1 in Human kidney tissue by immunohistochemistry (FFPE).

References

ab113815 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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