Overview

  • Product name
  • Description
    Rabbit polyclonal to SIPA1L1
  • Specificity
    ab91586 is specific for SIPA1L1 and will not recognize the other SIPA1 family proteins.
  • Tested applications
    Suitable for: ICC/IF, WB, ELISAmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    A 16 amino acid synthetic peptide from near the amino terminus of Human SIPA1L1 (NP_056371).

  • Positive control
    • Rat brain tissue lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab91586 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF
WB
ELISA
  • Application notes
    ELISA: Use at an assay dependent dilution.
    WB: Use at a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 200 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Relevance
      SIPA1L1 (Signal-induced proliferation associated-like protein 1) is a member of the SIPA1 family of RapGAPs. SIPA1L1 was initially identified as a binding partner and degradation target of the E6 oncoprotein of high-risk papillomaviruses. Recently, it was discovered that Casein kinase I epsilon (CKIe), a Wnt-regulated kinase that regulates Wnt/b-catenin signaling, also can bind to the carboxy-terminus of SIPA1L1. CKIe phosphorylates SIPA1L1, thereby reducing its stability and alleviating its inhibition of Rap1, a protein required for Wnt8/CKIe-mediated gastrulation during embryogenesis, suggesting SIPA1L1 plays important roles in embryo development as well as control of cell proliferation.
    • Cellular localization
      Intracellular
    • Database links
    • Alternative names
      • DKFZp686G1344 antibody
      • E6 targeted protein 1 antibody
      • E6TP1 antibody
      • H_DJ1140G11.1 antibody
      • High risk human papilloma viruses E6 oncoproteins targeted protein 1 antibody
      • KIAA0440 antibody
      • Signal induced proliferation associated 1 like 1 antibody
      • Signal induced proliferation associated 1 like protein 1 antibody
      • SIPA1 like protein 1 antibody
      • WUGSC:H_DJ1140G11.1 antibody
      see all

    Images

    • Immunofluorescence of SIPA1L1 in Human brain tissue with ab91586 at 20 ug/mL.

    • Immunohistochemistry of Human brain tissue with ab91586 at 5 μg/mL.

    • Lane 1 : Anti-SIPA1L1 antibody (ab91586) at 0.5 µg/ml
      Lane 2 : Anti-SIPA1L1 antibody (ab91586) at 1 µg/ml

      Lane 1 : Rat brain tissue lysate
      Lane 2 : Rat brain tissue lysate

      Lysates/proteins at 15 µg per lane.


      Predicted band size : 200 kDa

    References

    ab91586 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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