The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application notesFACS: Neat-1/10. Use 10µl of the suggested working dilution to 1x106 cells in 100µl.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionImmunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
Tissue specificityUbiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas.
Brain Ig like molecule with tyrosine based activation motifs antibody
Brain Ig-like molecule with tyrosine-based activation motifs antibody
Brain immunoglobulin like molecule with tyrosine based activation motifs antibody
CD172 antigen like family member A antibody
CD172 antigen-like family member A antibody
CD172a antigen antibody
Inhibitory receptor SHPS-1 antibody
Macrophage fusion receptor antibody
MYD 1 antibody
Myd 1 antigen antibody
MyD-1 antigen antibody
Protein tyrosine phosphatase non receptor type substrate 1 antibody
SHP substrate 1 antibody
Signal regulatory protein alpha 2 antibody
Signal regulatory protein alpha 3 antibody
Signal regulatory protein alpha antibody
Signal regulatory protein alpha type 2 antibody
Signal-regulatory protein alpha-1 antibody
Signal-regulatory protein alpha-2 antibody
Signal-regulatory protein alpha-3 antibody
Tyrosine phosphatase SHP substrate 1 antibody
Tyrosine protein phosphatase non receptor type substrate 1 antibody
Tyrosine-protein phosphatase non-receptor type substrate 1 antibody
References for Anti-SIRP alpha antibody [BL1H7] (FITC) (ab23772)
This product has been referenced in:
Domenech N et al. Identification of porcine macrophages with monoclonal antibodies in formalin-fixed, paraffin-embedded tissues. Vet Immunol Immunopathol94:77-81 (2003).
Read more (PubMed: 12842613) »
Alvarez B et al. A porcine cell surface receptor identified by monoclonal antibodies to SWC3 is a member of the signal regulatory protein family and associates with protein-tyrosine phosphatase SHP-1. Tissue Antigens55:342-51 (2000).
Read more (PubMed: 10852386) »