Overview

  • Product nameAnti-SIRP alpha antibody [BL1H7] (FITC)
    See all SIRP alpha primary antibodies
  • Description
    Mouse monoclonal [BL1H7] to SIRP alpha (FITC)
  • ConjugationFITC. Ex: 493nm, Em: 528nm
  • Tested applicationsSuitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Pig
  • Immunogen

    Porcine alveolar macrophages.

Properties

Applications

Our Abpromise guarantee covers the use of ab23772 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
  • Application notesFACS: Neat-1/10. Use 10µl of the suggested working dilution to 1x106 cells in 100µl.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionImmunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
    • Tissue specificityUbiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas.
    • Sequence similaritiesContains 2 Ig-like C1-type (immunoglobulin-like) domains.
      Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    • Post-translational
      modifications
      N-glycosylated.
      Phosphorylated on tyrosine residues in response to stimulation with EGF, growth hormone, insulin and PDGF. Dephosphorylated by PTPN11.
    • Cellular localizationMembrane.
    • Information by UniProt
    • Alternative names
      • Signal regulatory protein alpha type 1 antibody
      • Bit antibody
      • Brain Ig like molecule with tyrosine based activation motifs antibody
      • Brain Ig-like molecule with tyrosine-based activation motifs antibody
      • Brain immunoglobulin like molecule with tyrosine based activation motifs antibody
      • CD172 antigen like family member A antibody
      • CD172 antigen-like family member A antibody
      • CD172a antibody
      • CD172a antigen antibody
      • Inhibitory receptor SHPS-1 antibody
      • Macrophage fusion receptor antibody
      • MFR antibody
      • MYD 1 antibody
      • Myd 1 antigen antibody
      • MyD-1 antigen antibody
      • p84 antibody
      • Protein tyrosine phosphatase non receptor type substrate 1 antibody
      • PTPNS1 antibody
      • SHP substrate 1 antibody
      • SHPS-1 antibody
      • SHPS1 antibody
      • SHPS1_HUMAN antibody
      • Signal regulatory protein alpha 2 antibody
      • Signal regulatory protein alpha 3 antibody
      • Signal regulatory protein alpha antibody
      • Signal regulatory protein alpha type 2 antibody
      • Signal-regulatory protein alpha-1 antibody
      • Signal-regulatory protein alpha-2 antibody
      • Signal-regulatory protein alpha-3 antibody
      • SIRP antibody
      • Sirp-alpha-1 antibody
      • Sirp-alpha-2 antibody
      • Sirp-alpha-3 antibody
      • SIRPA antibody
      • SIRPalpha antibody
      • SIRPalpha1 antibody
      • SIRPalpha2 antibody
      • SIRPalpha3 antibody
      • Tyrosine phosphatase SHP substrate 1 antibody
      • Tyrosine protein phosphatase non receptor type substrate 1 antibody
      • Tyrosine-protein phosphatase non-receptor type substrate 1 antibody
      see all

    References for Anti-SIRP alpha antibody [BL1H7] (FITC) (ab23772)

    This product has been referenced in:
    • Domenech N  et al. Identification of porcine macrophages with monoclonal antibodies in formalin-fixed, paraffin-embedded tissues. Vet Immunol Immunopathol 94:77-81 (2003). Read more (PubMed: 12842613) »
    • Alvarez B  et al. A porcine cell surface receptor identified by monoclonal antibodies to SWC3 is a member of the signal regulatory protein family and associates with protein-tyrosine phosphatase SHP-1. Tissue Antigens 55:342-51 (2000). Read more (PubMed: 10852386) »

    See all 3 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"