The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
PBS with 0.1% BSA 0.02% sodium azide pH7.2
Signal regulatory protein alpha type 1
Brain Ig like molecule with tyrosine based activation motifs
Brain Ig-like molecule with tyrosine-based activation motifs
Brain immunoglobulin like molecule with tyrosine based activation motifs
CD172 antigen like family member A
CD172 antigen-like family member A
Inhibitory receptor SHPS-1
Macrophage fusion receptor
Myd 1 antigen
Protein tyrosine phosphatase non receptor type substrate 1
SHP substrate 1
Signal regulatory protein alpha
Signal regulatory protein alpha 2
Signal regulatory protein alpha 3
Signal regulatory protein alpha type 2
Signal-regulatory protein alpha-1
Signal-regulatory protein alpha-2
Signal-regulatory protein alpha-3
Tyrosine phosphatase SHP substrate 1
Tyrosine protein phosphatase non receptor type substrate 1
Tyrosine-protein phosphatase non-receptor type substrate 1
FunctionImmunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
Tissue specificityUbiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas.