Anti-SIRT1 antibody [E104] (ab32441)

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ab32441 has been referenced in 56 publications.

  • Li FL  et al. Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis. Nat Commun 9:508 (2018). PubMed: 29410405
  • Sun T  et al. SIRT1 induces epithelial-mesenchymal transition by promoting autophagic degradation of E-cadherin in melanoma cells. Cell Death Dis 9:136 (2018). IHC . PubMed: 29374154
  • Liu SY  et al. Hydrogen Sulfide Inhibits Chronic Unpredictable Mild Stress-Induced Depressive-Like Behavior by Upregulation of Sirt-1: Involvement in Suppression of Hippocampal Endoplasmic Reticulum Stress. Int J Neuropsychopharmacol 20:867-876 (2017). Rat . PubMed: 28482013
  • Rizzo A  et al. SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage. Nucleic Acids Res 45:1820-1834 (2017). WB . PubMed: 27923994
  • Wang Y  et al. HIC1 and miR-23~27~24 clusters form a double-negative feedback loop in breast cancer. Cell Death Differ 24:421-432 (2017). PubMed: 28009350
  • Bu P  et al. MicroRNA-9 inhibits the proliferation and migration of malignant melanoma cells via targeting sirituin 1. Exp Ther Med 14:931-938 (2017). PubMed: 28810544
  • Jin J  et al. SIRT1 promotes the proliferation and metastasis of human pancreatic cancer cells. Tumour Biol 39:1010428317691180 (2017). IHC ; Human . PubMed: 28351313
  • Zhang S  et al. Co-ordinated overexpression of SIRT1 and STAT3 is associated with poor survival outcome in gastric cancer patients. Oncotarget 8:18848-18860 (2017). IHC-P ; Human . PubMed: 28061480
  • Xu X  et al. LncRNA H19 promotes the differentiation of bovine skeletal muscle satellite cells by suppressing Sirt1/FoxO1. Cell Mol Biol Lett 22:10 (2017). WB ; Cow . PubMed: 28652859
  • Thangjam GS  et al. Hsp90 inhibition suppresses NF-?B transcriptional activation via Sirt-2 in human lung microvascular endothelial cells. Am J Physiol Lung Cell Mol Physiol 310:L964-74 (2016). PubMed: 27036868
  • Lin SY & Peng F Association of SIRT1 and HMGA1 expression in non-small cell lung cancer. Oncol Lett 11:782-788 (2016). IHC-P ; Human . PubMed: 26834854
  • Pan W  et al. Resveratrol Protects against TNF-a-Induced Injury in Human Umbilical Endothelial Cells through Promoting Sirtuin-1-Induced Repression of NF-KB and p38 MAPK. PLoS One 11:e0147034 (2016). Human . PubMed: 26799794
  • Fukuda T  et al. Autophagy inhibition augments resveratrol-induced apoptosis in Ishikawa endometrial cancer cells. Oncol Lett 12:2560-2566 (2016). Human . PubMed: 27698828
  • Sharif T  et al. The NAD(+) salvage pathway modulates cancer cell viability via p73. Cell Death Differ 23:669-80 (2016). PubMed: 26586573
  • Chen Y  et al. Hydroquinone-induced malignant transformation of TK6 cells by facilitating SIRT1-mediated p53 degradation and up-regulating KRAS. Toxicol Lett 259:133-42 (2016). WB, IHC-P ; Human . PubMed: 27515134
  • Wan X  et al. SIRT1-PGC1a-NF?B Pathway of Oxidative and Inflammatory Stress during Trypanosoma cruzi Infection: Benefits of SIRT1-Targeted Therapy in Improving Heart Function in Chagas Disease. PLoS Pathog 12:e1005954 (2016). WB ; Mouse . PubMed: 27764247
  • Bartosch C  et al. Assessing sirtuin expression in endometrial carcinoma and non-neoplastic endometrium. Oncotarget 7:1144-54 (2016). WB, IHC-P ; Human . PubMed: 26701732
  • Wang Y  et al. SIRT1 increases YAP- and MKK3-dependent p38 phosphorylation in mouse liver and human hepatocellular carcinoma. Oncotarget 7:11284-98 (2016). WB, IHC . PubMed: 26824501
  • Li C  et al. SIRT1 expression is associated with poor prognosis of lung adenocarcinoma. Onco Targets Ther 8:977-84 (2015). IHC-P ; Human . PubMed: 25995644
  • Benard A  et al. Nuclear expression of histone deacetylases and their histone modifications predicts clinical outcome in colorectal cancer. Histopathology 66:270-82 (2015). IHC-P ; Human . PubMed: 25307864
  • Mohan M  et al. Dysregulated miR-34a-SIRT1-acetyl p65 axis is a potential mediator of immune activation in the colon during chronic simian immunodeficiency virus infection of rhesus macaques. J Immunol 194:291-306 (2015). PubMed: 25452565
  • McGlynn LM  et al. SIRT3 & SIRT7: Potential Novel Biomarkers for Determining Outcome in Pancreatic Cancer Patients. PLoS One 10:e0131344 (2015). IHC ; Human . PubMed: 26121130
  • Zhang X  et al. The expression and correlation of SIRT1 and Phospho-SIRT1 in colorectal cancer. Int J Clin Exp Med 8:809-17 (2015). WB, IHC-P ; Human . PubMed: 25785061
  • Sun H  et al. NUT Midline Carcinoma: Morphoproteomic Characterization with Genomic and Therapeutic Correlates. Ann Clin Lab Sci 45:692-701 (2015). PubMed: 26663801
  • Curtil C  et al. The metabolic sensors FXRa, PGC-1a, and SIRT1 cooperatively regulate hepatitis B virus transcription. FASEB J 28:1454-63 (2014). Human . PubMed: 24297698
  • Kiga K  et al. Comprehensive silencing of target-sharing microRNAs is a mechanism for SIRT1 overexpression in cancer. RNA Biol 11:1347-54 (2014). WB ; Human . PubMed: 25483038
  • Jiang W  et al. SIRT1 protects against apoptosis by promoting autophagy in degenerative human disc nucleus pulposus cells. Sci Rep 4:7456 (2014). Human . PubMed: 25503852
  • Shen W  et al. Acupuncture promotes white adipose tissue browning by inducing UCP1 expression on DIO mice. BMC Complement Altern Med 14:501 (2014). PubMed: 25514854
  • Hao C  et al. Overexpression of SIRT1 promotes metastasis through epithelial-mesenchymal transition in hepatocellular carcinoma. BMC Cancer 14:978 (2014). IHC-P ; Human . PubMed: 25522783
  • Antoniali G  et al. SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements. Mol Biol Cell 25:532-47 (2014). WB ; Human . PubMed: 24356447
  • Ren JH  et al. Sirtuin 1 regulates hepatitis B virus transcription and replication by targeting transcription factor AP-1. J Virol 88:2442-51 (2014). PubMed: 24335313
  • Simmons GE  et al. Frizzled 7 expression is positively regulated by SIRT1 and ß-catenin in breast cancer cells. PLoS One 9:e98861 (2014). WB ; Human . PubMed: 24897117
  • Chen X  et al. Sirt1 is a tumor promoter in lung adenocarcinoma. Oncol Lett 8:387-393 (2014). IHC-P ; Human . PubMed: 24959282
  • Derr RS  et al. High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased relapse in breast cancer patients. BMC Cancer 14:604 (2014). IHC-P ; Human . PubMed: 25139823
  • Raynes R  et al. The SIRT1 modulators AROS and DBC1 regulate HSF1 activity and the heat shock response. PLoS One 8:e54364 (2013). WB ; Human . PubMed: 23349863
  • Holloway KR  et al. SIRT1 positively regulates breast cancer associated human aromatase (CYP19A1) expression. Mol Endocrinol 27:480-90 (2013). WB ; Human . PubMed: 23340254
  • Yu XM  et al. The Expression of SIRT1 and DBC1 in Laryngeal and Hypopharyngeal Carcinomas. PLoS One 8:e66975 (2013). IHC-P . PubMed: 23805287
  • Moschen AR  et al. Adipose tissue and liver expression of SIRT1, 3, and 6 increase after extensive weight loss in morbid obesity. J Hepatol N/A:N/A (2013). PubMed: 23928404
  • Stenzinger A  et al. High SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinoma. BMC Cancer 13:450 (2013). WB, IHC-P ; Human . PubMed: 24088390
  • Tanikawa M  et al. Role of multifunctional transcription factor TFII-I and putative tumour suppressor DBC1 in cell cycle and DNA double strand damage repair. Br J Cancer 109:3042-8 (2013). Human . PubMed: 24231951
  • Koizume S  et al. HIF2a-Sp1 interaction mediates a deacetylation-dependent FVII-gene activation under hypoxic conditions in ovarian cancer cells. Nucleic Acids Res 40:5389-401 (2012). PubMed: 22402494
  • Yamagata Y  et al. Lentiviral transduction of CD34(+) cells induces genome-wide epigenetic modifications. PLoS One 7:e48943 (2012). ICC/IF ; Human . PubMed: 23145033
  • Yuan H  et al. Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis. Blood 119:1904-14 (2012). WB ; Human . PubMed: 22207735
  • Li JY  et al. Dynamic distribution of linker histone H1.5 in cellular differentiation. PLoS Genet 8:e1002879 (2012). ChIP ; Human . PubMed: 22956909
  • Tanikawa M  et al. Multifunctional transcription factor TFII-I is an activator of BRCA1 function. Br J Cancer 104:1349-55 (2011). Human . PubMed: 21407215
  • Fiedler J  et al. MicroRNA-24 regulates vascularity after myocardial infarction. Circulation 124:720-30 (2011). WB, IHC-Fr ; Mouse . PubMed: 21788589
  • Niederer F  et al. SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance. Ann Rheum Dis 70:1866-73 (2011). WB ; Human . PubMed: 21742641
  • Chen J  et al. Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth. Cancer Res 71:4138-49 (2011). IHC-P ; Human . PubMed: 21527554
  • Sestito R  et al. STAT3-dependent effects of IL-22 in human keratinocytes are counterregulated by sirtuin 1 through a direct inhibition of STAT3 acetylation. FASEB J 25:916-27 (2011). IHC-Fr ; Human . PubMed: 21098725
  • Orecchia A  et al. Sirtinol treatment reduces inflammation in human dermal microvascular endothelial cells. PLoS One 6:e24307 (2011). IHC-P ; Human . PubMed: 21931678
  • Peck B  et al. SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2. Mol Cancer Ther 9:844-55 (2010). WB ; Human . PubMed: 20371709
  • Levin VA  et al. Different changes in protein and phosphoprotein levels result from serum starvation of high-grade glioma and adenocarcinoma cell lines. J Proteome Res 9:179-91 (2010). WB ; Human . PubMed: 19894763
  • Han L  et al. SIRT1 is regulated by a PPAR{gamma}-SIRT1 negative feedback loop associated with senescence. Nucleic Acids Res 38:7458-71 (2010). WB ; Human . PubMed: 20660480
  • Jung-Hynes B  et al. Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition? J Biol Chem 284:3823-32 (2009). IP ; Human . PubMed: 19075016
  • Menghini R  et al. MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1. Circulation 120:1524-32 (2009). PubMed: 19786632
  • Zhang Y  et al. Deacetylation of cortactin by SIRT1 promotes cell migration. Oncogene 28:445-60 (2009). WB, IHC-P ; Human . PubMed: 18850005


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