Overview

  • Product nameAnti-SIRT2 antibody
    See all SIRT2 primary antibodies
  • Description
    Mouse monoclonal to SIRT2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: YTQNIDTLER IAGLEQEDLV EAHGTFYTSH CVSASCRHEY PLSWMKEKIF SEVTPKCEDC QSLVKPDIVF FGESLPARFF SCMQSDFLKV DLLLVMGTSL , corresponding to amino acids 128-227 of Human SIR2/ SIRT2

Properties

Applications

Our Abpromise guarantee covers the use of ab56904 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionNAD-dependent protein deacetylase, which deacetylates the 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton.
    • Tissue specificityWidely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network.
    • Sequence similaritiesBelongs to the sirtuin family.
      Contains 1 deacetylase sirtuin-type domain.
    • Developmental stagePeaks during mitosis. After mitosis, it is probably degraded by the 26S proteasome.
    • Post-translational
      modifications
      Phosphorylated at the G2/M transition of the cell cycle.
    • Cellular localizationCytoplasm > cytoskeleton. Colocalizes with microtubules.
    • Information by UniProt
    • Database links
    • Alternative names
      • FLJ35621 antibody
      • FLJ37491 antibody
      • NAD dependent deacetylase sirtuin 2 antibody
      • NAD-dependent deacetylase sirtuin-2 antibody
      • NAD-dependent protein deacetylase sirtuin-2 antibody
      • Regulatory protein SIR2 homolog 2 antibody
      • Silencing information regulator 2 like antibody
      • Silent information regulator 2 antibody
      • SIR2 antibody
      • SIR2 like protein 2 antibody
      • Sir2 related protein type 2 antibody
      • SIR2, S. cerevisiae, homolog-loke 2 antibody
      • SIR2-like protein 2 antibody
      • SIR2L antibody
      • SIR2L2 antibody
      • SIRT2 antibody
      • SIRT2_HUMAN antibody
      • Sirtuin (silent mating type information regulation 2 homolog) 2 (S.cerevisiae) antibody
      • Sirtuin 2 antibody
      • Sirtuin type 2 antibody
      see all

    Anti-SIRT2 antibody images

    • Western blot against tagged recombinant protein immunogen using ab56904 SIR2 / SIRT2 antibody at 1ug/ml. Predicted band size of immunogen is 34 kDa

    References for Anti-SIRT2 antibody (ab56904)

    ab56904 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"