Anti-SIT antibody [SIT-01] (Phycoerythrin) (ab36418)

Overview

  • Product name
    Anti-SIT antibody [SIT-01] (Phycoerythrin)
    See all SIT primary antibodies
  • Description
    Mouse monoclonal [SIT-01] to SIT (Phycoerythrin)
  • Conjugation
    Phycoerythrin. Ex: 488nm, Em: 575nm
  • Specificity
    ab36418 reacts with SIT.
  • Tested applications
    Suitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment (Human) Bacterially produced recombinant intracellular fragment of human SIT.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C.
  • Storage buffer
    Preservative: 15mM Sodium Azide
    Constituents: 0.2% BSA, PBS
  • Concentration information loading...
  • Purification notes
    The conjugate was purified by size-exclusion chromatography
  • Clonality
    Monoclonal
  • Clone number
    SIT-01
  • Isotype
    IgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab36418 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt 1/50.

Target

  • Function
    Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive selection of T-cells.
  • Tissue specificity
    Specifically expressed in T- and B-cells. Present in plasma cells but not in germinal center B-cells (at protein level). Expressed in T- and B-cell lymphoma.
  • Post-translational
    modifications
    Phosphorylated on tyrosines by LCK, FYN or ZAP70 upon TCR activation; which leads to the recruitment of PTPN11, GRB2 and CSK.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • gp30/40 antibody
    • SHP intracting transmembrane adapter protein antibody
    • SHP2-interacting transmembrane adapter protein antibody
    • Signaling threshold-regulating transmembrane adapter 1 antibody
    • SIT antibody
    • Sit1 antibody
    • SIT1_HUMAN antibody
    • Suppression inducing transmembrane adapter 1 antibody
    • Suppression-inducing transmembrane adapter 1 antibody
    see all

Images

  • Flow Cytometry analysis of human peripheral blood cells labeling SIT with Anti-SIT antibody [SIT-01] (Phycoerythrin) (ab36418).

References

ab36418 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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