Overview

  • Product name
    Sivelestat
  • Description
    Potent, selective, substrate competitive neutrophil elastase inhibitor
  • Biological description
    Potent, selective, substrate competitive neutrophil elastase inhibitor (IC50 values are 19-49 nM and 5.6 μM for leukocyte and pancreas elastase respectively). Suppresses neutrophil-induced capillary permeability and leukocyte kinetics. Active in vivo.

Properties

  • Chemical name
    2-[[2-[[4-(2,2-Dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetic acid
  • Molecular weight
    434.46
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C20H22N2O7S
  • CAS Number
    127373-66-4
  • PubChem identifier
    107706
  • Storage instructions
    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Masood A  et al. Neutrophil elastase-induced elastin degradation mediates macrophage influx and lung injury in 60% O2-exposed neonatal rats. Am J Physiol Lung Cell Mol Physiol 309:L53-62 (2015). Read more (PubMed: 26136527) »
  • Muley MM  et al. Neutrophil Elastase-Induced Inflammation and Pain in Mouse Knee Joints via Activation of Proteinase Activated Receptor-2. Br J Pharmacol : (2015). Read more (PubMed: 26140667) »
  • Kim DH  et al. Effect of a neutrophil elastase inhibitor on ventilator-induced lung injury in rats. J Thorac Dis 6:1681-9 (2014). Read more (PubMed: 25589960) »

See 0 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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