Overview

  • Product nameAnti-SKA2 antibody
    See all SKA2 primary antibodies
  • Description
    Rabbit polyclonal to SKA2
  • Specificityab75345 reacts specifically with SKA2 protein
  • Tested applicationsSuitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide derived from the C terminal domain of human SKA2

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: Whole serum
  • PurityWhole antiserum
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab75345 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use at an assay dependent concentration.
WB 1/200 - 1/2000. Predicted molecular weight: 14 kDa.

Target

  • FunctionComponent of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it is required for SKA1 localization.
  • Sequence similaritiesBelongs to the SKA2 family.
  • Cellular localizationCytoplasm > cytoskeleton > spindle. Chromosome > centromere > kinetochore. Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. Localizes to both the mitotic spindle and kinetochore-associated proteins.
  • Information by UniProt
  • Database links
  • Alternative names
    • FAM33A antibody
    • Family with sequence similarity 33, member A antibody
    • FLJ12758 antibody
    • MGC110975 antibody
    • Protein FAM33A antibody
    • SKA 2 antibody
    • SKA2 antibody
    • SKA2_HUMAN antibody
    • Spindle and kinetochore associated complex subunit 2 antibody
    • Spindle and kinetochore associated protein 2 antibody
    • Spindle and kinetochore-associated protein 2 antibody
    • Spindle and KT (kinetochore) associated 2 antibody
    • Spindle and KT associated 2 antibody
    see all

References for Anti-SKA2 antibody (ab75345)

ab75345 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"