Overview

  • Product nameAnti-SKAP55 antibody
    See all SKAP55 primary antibodies
  • Description
    Mouse monoclonal to SKAP55
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: MQAAALPEEI RWLLEDAEEF LAEGLRNENL SAVARDHRDH ILRGFQQIKA RYYWDFQPQG GDIGQDSSDD NHSGTLGLSL TSDAPFLSDY QDEGMEDIVK , corresponding to amino acids 1-101 of Human SKAP55

Properties

Applications

Our Abpromise guarantee covers the use of ab56336 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionPositively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.
    • Tissue specificityHighly expressed in thymocytes and peripheral blood lymphocytes. Also expressed in spleen cells and testis. Present in T-cells (at protein level).
    • Sequence similaritiesBelongs to the SKAP family.
      Contains 1 PH domain.
      Contains 1 SH3 domain.
    • DomainThe SH3 domain interacts with FYB.
    • Post-translational
      modifications
      Phosphorylated on tyrosines. Phosphorylation by FYN on Tyr-271 is required for GRB2 interaction. Phosphorylation by FYN on Tyr-295 abolishes interaction with FYB. Tyr-232 is dephosphorylated by PTPRC.
    • Cellular localizationCytoplasm. Nucleus. Cell membrane. Upon T-cell stimulation, translocates to lipid rafts at the cell membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • pp55 antibody
      • SCAP 1 antibody
      • SCAP1 antibody
      • SKAP 1 antibody
      • SKAP 55 antibody
      • SKAP-55 antibody
      • Skap1 antibody
      • SKAP1_HUMAN antibody
      • SKAP55 adaptor protein antibody
      • SRC family associated phosphoprotein 1 antibody
      • Src family-associated phosphoprotein 1 antibody
      • Src kinase associated phosphoprotein 1 antibody
      • SRC kinase associated phosphoprotein 55 kD antibody
      • Src kinase associated phosphoprotein of 55 kDa antibody
      • Src kinase-associated phosphoprotein 1 antibody
      • Src kinase-associated phosphoprotein of 55 kDa antibody
      see all

    Anti-SKAP55 antibody images



    • Predicted band size : 41 kDa
      SKAP55 antibody (ab56336) at 1ug/lane + Jurkat cell lysate at 25ug/lane.

    References for Anti-SKAP55 antibody (ab56336)

    ab56336 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab56336.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"