Overview

  • Product name
    SKF89976A hydrochloride
  • Description
    Highly selective GAT-1 inhibitor
  • Biological description
    A potent GABA uptake inhibitor, highly selective for GAT-1 (IC50 values are 0.13 (hGAT-1), 550 ( rGAT-2), 944 ( hGAT-3) and 7210 μM (hBGT-1)). Brain penetrant, orally active and anticovulsant in vivo.

    Also available in simple stock solutions (ab146705) - add 1 ml of water to get an exact, ready-to-use concentration.
  • Purity
    > 99%

Properties

References

This product has been referenced in:
  • Krause S & Schwarz W Identification and selective inhibition of the channel mode of the neuronal GABA transporter 1. Mol Pharmacol 68:1728-35 (2005). Read more (PubMed: 16150932) »
  • Borden LA  et al. Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur J Pharmacol 269:219-24 (1994). Read more (PubMed: 7851497) »
  • Swinyard EA  et al. Anticonvulsant profiles of the potent and orally active GABA uptake inhibitors SK&F 89976-A and SK&F 100330-A and four prototype antiepileptic drugs in mice and rats. Epilepsia 32:569-77 (0). Read more (PubMed: 1831122) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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