Overview

  • Product name
  • Description
    Rabbit polyclonal to SKIP
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment, corresponding to amino acids 183-430 of Human SKIP (BC004362).

  • Positive control
    • Human fetal heart lysate; Human fetal skeletal muscle tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab113441 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 51 kDa (predicted molecular weight: 51 kDa).
IHC-P 1/100 - 1/500.

Target

  • Function
    Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-triphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. May negatively regulate assembly of the actin cytoskeleton.
  • Tissue specificity
    Ubiquitously expressed with highest levels in skeletal muscle, heart and kidney.
  • Sequence similarities
    Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type II family.
  • Cellular localization
    Endoplasmic reticulum. Following stimulation with EGF, translocates to membrane ruffles.
  • Information by UniProt
  • Database links
  • Alternative names
    • 43 kDa form skeletal muscle and kidney enriched inositol phosphatase antibody
    • Inositol polyphosphate 5-phosphatase K antibody
    • INP5K_HUMAN antibody
    • INPP5K antibody
    • muscle and kidney-enriched inositol phosphatase antibody
    • PPS antibody
    • skeletal muscle and kidney enriched inositol phosphatase antibody
    • Skeletal muscle and kidney-enriched inositol phosphatase antibody
    see all

Images

  • Anti-SKIP antibody (ab113441) at 1/500 dilution + Human fetal heart lysate

    Predicted band size : 51 kDa
  • ab113441 at 1/100 dilution staining SKIP in Formalin-fixed, Paraffin-embedded Human fetal skeletal muscle tissue by Immunohistochemistry. Note cytoplasmic staining.

References

ab113441 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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