Overview

  • Product name
  • Description
    Mouse polyclonal to SKIP
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length human SKIP protein

  • Positive control
    • Transfected 293T cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab67715 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 51 kDa.

Target

  • Function
    Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-triphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. May negatively regulate assembly of the actin cytoskeleton.
  • Tissue specificity
    Ubiquitously expressed with highest levels in skeletal muscle, heart and kidney.
  • Sequence similarities
    Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type II family.
  • Cellular localization
    Endoplasmic reticulum. Following stimulation with EGF, translocates to membrane ruffles.
  • Information by UniProt
  • Database links
  • Alternative names
    • 43 kDa form skeletal muscle and kidney enriched inositol phosphatase antibody
    • Inositol polyphosphate 5-phosphatase K antibody
    • INP5K_HUMAN antibody
    • INPP5K antibody
    • muscle and kidney-enriched inositol phosphatase antibody
    • PPS antibody
    • skeletal muscle and kidney enriched inositol phosphatase antibody
    • Skeletal muscle and kidney-enriched inositol phosphatase antibody
    see all

Images

  • All lanes : Anti-SKIP antibody (ab67715) at 1/500 dilution

    Lane 1 : SKIP transfected 293T cell lysate
    Lane 2 : non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 51 kDa
    Observed band size : 51 kDa

References

This product has been referenced in:
  • Wu MY  et al. SNW1 is a critical regulator of spatial BMP activity, neural plate border formation, and neural crest specification in vertebrate embryos. PLoS Biol 9:e1000593 (2011). WB . Read more (PubMed: 21358802) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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