Anti-SLAM / CD150 antibody (ab82228)

Overview

  • Product nameAnti-SLAM / CD150 antibody
    See all SLAM / CD150 primary antibodies
  • Description
    Rabbit polyclonal to SLAM / CD150
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    KLH conjugated synthetic peptide corresponding to amino acid residues surrounding Y307 of human SLAM/ CD150

  • Positive control
    • mouse heart tissue lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab82228 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/50 - 1/100. Predicted molecular weight: 37 kDa.
ELISA 1/1000.

Target

  • FunctionHigh-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.
  • Tissue specificityConstitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes and a proportion of B-cells, and is rapidly induced on naive T-cells after activation.
  • Sequence similaritiesContains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • DomainThe most membrane-proximal SH2-binding motif interacts with SH2 domain of SH2D1A and does not need to be phosphorylated on tyrosine residues.
  • Post-translational
    modifications
    Phosphorylated by FYN.
  • Cellular localizationCell membrane. Present on the surface of B-cells and T-cells.
  • Information by UniProt
  • Database links
  • Alternative names
    • 4933415F16 antibody
    • AA177906 antibody
    • CD 150 antibody
    • CD150 antibody
    • CD150 antigen antibody
    • CDw150 antibody
    • Estm51 antibody
    • Ipo 3 antibody
    • IPO-3 antibody
    • Ipo3 antibody
    • MGC151472 antibody
    • MGC151476 antibody
    • OTTHUMP00000025670 antibody
    • OTTHUMP00000060252 antibody
    • RGD1560634 antibody
    • Signaling lymphocytic activation molecule antibody
    • Signaling lymphocytic activation molecule family member 1 antibody
    • Signaling lymphocytic activation molecule family member 1, isoform CRA_a antibody
    • Signaling lymphocytic activation molecule family member 1, isoform CRA_b antibody
    • Signaling lymphocytic activation molecule precursor antibody
    • Slaf1 antibody
    • SLAF1_HUMAN antibody
    • SLAM family, member 1 antibody
    • Slamf 1 antibody
    • SLAMF1 antibody
    • SLAMF1 protein antibody
    see all

Anti-SLAM / CD150 antibody images

References for Anti-SLAM / CD150 antibody (ab82228)

ab82228 has not yet been referenced specifically in any publications.

Product Wall

Abcam has not validated the combination of species/application used in this Abreview.
Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Sample Dog Tissue sections (spleen)
Antigen retrieval step Heat mediated - Buffer/Enzyme Used: 10 mM citrate, pH6.0
Permeabilization No
Specification spleen
Blocking step Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 10% · Temperature: 25°C
Fixative Formaldehyde
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Submitted May 19 2016

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"