Anti-SLAM / CD150 antibody [IPO-3] - Azide free (ab183269)

Overview

  • Product name
    Anti-SLAM / CD150 antibody [IPO-3] - Azide free
    See all SLAM / CD150 primary antibodies
  • Description
    Mouse monoclonal [IPO-3] to SLAM / CD150 - Azide free
  • Specificity
    This antibody is specific for SLAM.
  • Tested applications
    Suitable for: IHC-Fr, Flow Cyt, ELISA, IP, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Epitope
    The exact epitope recognised by this antibody has not been mapped.
  • General notes


    A novel glycoprotein of 70kDa, designated SLAM (Signaling Lymphocyte Activation Molecule) / CDw150, that belongs to the immunoglobulin gene superfamily and is involved in T-cell stimulation. SLAM is constitutively expressed on peripheral blood memory T cells, T-cell clones, immature thymocytes, and a proportion of B cells, and is rapidly induced on naive T cells after activation. Activated B cells express the membrane-bound form of SLAM and the soluble and cytoplasmic isoforms of SLAM, and that the expression levels of membrane-bound SLAM on B cells are rapidly regulated after activation in vitro. It is suggested that signaling through homophilic SLAM-SLAM binding during B-B and B-T cell interactions enhances the expansion and differentiation of activated B cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab183269 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr 1/100.
Flow Cyt 1/750. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
ELISA 1/750.
IP Use at an assay dependent concentration.
ICC/IF Use at an assay dependent concentration. PubMed: 21379338

Target

  • Function
    High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.
  • Tissue specificity
    Constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes and a proportion of B-cells, and is rapidly induced on naive T-cells after activation.
  • Sequence similarities
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Domain
    The most membrane-proximal SH2-binding motif interacts with SH2 domain of SH2D1A and does not need to be phosphorylated on tyrosine residues.
  • Post-translational
    modifications
    Phosphorylated by FYN.
  • Cellular localization
    Cell membrane. Present on the surface of B-cells and T-cells.
  • Information by UniProt
  • Database links
  • Alternative names
    • 4933415F16 antibody
    • AA177906 antibody
    • CD 150 antibody
    • CD150 antibody
    • CD150 antigen antibody
    • CDw150 antibody
    • Estm51 antibody
    • Ipo 3 antibody
    • IPO-3 antibody
    • Ipo3 antibody
    • MGC151472 antibody
    • MGC151476 antibody
    • OTTHUMP00000025670 antibody
    • OTTHUMP00000060252 antibody
    • RGD1560634 antibody
    • Signaling lymphocytic activation molecule antibody
    • Signaling lymphocytic activation molecule family member 1 antibody
    • Signaling lymphocytic activation molecule family member 1, isoform CRA_a antibody
    • Signaling lymphocytic activation molecule family member 1, isoform CRA_b antibody
    • Signaling lymphocytic activation molecule precursor antibody
    • Slaf1 antibody
    • SLAF1_HUMAN antibody
    • SLAM family, member 1 antibody
    • Slamf 1 antibody
    • SLAMF1 antibody
    • SLAMF1 protein antibody
    see all

References

This product has been referenced in:
  • Noyce RS  et al. Tumor Cell Marker PVRL4 (Nectin 4) Is an Epithelial Cell Receptor for Measles Virus. PLoS Pathog 7:e1002240 (2011). Read more (PubMed: 21901103) »
  • Avota E  et al. DC-SIGN Mediated Sphingomyelinase-Activation and Ceramide Generation Is Essential for Enhancement of Viral Uptake in Dendritic Cells. PLoS Pathog 7:e1001290 (2011). ICC/IF ; Human . Read more (PubMed: 21379338) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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