Anti-SLAM / CD150 (phospho Y281) antibody (ab174348)

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Overview

  • Product name
    Anti-SLAM / CD150 (phospho Y281) antibody
    See all SLAM / CD150 primary antibodies
  • Description
    Rabbit polyclonal to SLAM / CD150 (phospho Y281)
  • Host species
    Rabbit
  • Tested applications
    Suitable for: Dot blotmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human SLAM/ CD150 aa 265-295 (phospho Y281) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: Q13291

Properties

Applications

Our Abpromise guarantee covers the use of ab174348 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Dot blot 1/500.

Target

  • Function
    High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.
  • Tissue specificity
    Constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes and a proportion of B-cells, and is rapidly induced on naive T-cells after activation.
  • Sequence similarities
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Domain
    The most membrane-proximal SH2-binding motif interacts with SH2 domain of SH2D1A and does not need to be phosphorylated on tyrosine residues.
  • Post-translational
    modifications
    Phosphorylated by FYN.
  • Cellular localization
    Cell membrane. Present on the surface of B-cells and T-cells.
  • Information by UniProt
  • Database links
    • Alternative names
      • 4933415F16 antibody
      • AA177906 antibody
      • CD 150 antibody
      • CD150 antibody
      • CD150 antigen antibody
      • CDw150 antibody
      • Estm51 antibody
      • Ipo 3 antibody
      • IPO-3 antibody
      • Ipo3 antibody
      • MGC151472 antibody
      • MGC151476 antibody
      • OTTHUMP00000025670 antibody
      • OTTHUMP00000060252 antibody
      • RGD1560634 antibody
      • Signaling lymphocytic activation molecule antibody
      • Signaling lymphocytic activation molecule family member 1 antibody
      • Signaling lymphocytic activation molecule family member 1, isoform CRA_a antibody
      • Signaling lymphocytic activation molecule family member 1, isoform CRA_b antibody
      • Signaling lymphocytic activation molecule precursor antibody
      • Slaf1 antibody
      • SLAF1_HUMAN antibody
      • SLAM family, member 1 antibody
      • Slamf 1 antibody
      • SLAMF1 antibody
      • SLAMF1 protein antibody
      see all

    Images

    • Dot Blot - Anti-SLAM / CD150 antibody (ab174348)
      Dot Blot - Anti-SLAM / CD150 antibody (ab174348)

      Dot blot analysis of ab174348 at 0.5 ug/ml on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed.

    References

    ab174348 has not yet been referenced specifically in any publications.

    Publishing research using ab174348? Please let us know so that we can cite the reference in this datasheet.

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