Overview

  • Product nameAnti-SLAMF7 antibody [162] (Phycoerythrin)
    See all SLAMF7 primary antibodies
  • Description
    Mouse monoclonal [162] to SLAMF7 (Phycoerythrin)
  • ConjugationPhycoerythrin. Ex: 488nm, Em: 575nm
  • Tested applicationsSuitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    SLAMF7 extracellular domain fused with Human IgG1 constant regions.

  • Positive control
    • Normal Human peripheral blood cells

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C.
  • Storage bufferPreservative: 0.09% Sodium Azide
    Constituents: PBS, BSA and/or Gelatin, pH 7.2
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityMonoclonal
  • Clone number162
  • IsotypeIgG2b
  • Light chain typekappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab95827 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use 5µl for 106 cells. ab91532-Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody.

Target

  • RelevanceSLAMF7 contains one Ig-like C2-type (immunoglobulin-like) domain. Isoform 1 mediates NK cell activation through a SAP-independent extracellular signal-regulated ERK-mediated pathway. It may play a role in lymphocyte adhesion. Isoform 3 does not mediate any activation. SAP can bind the cytoplasmic tail of isoform 1 when phosphorylated in the presence of Fyn (in vitro). SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines. The isoform 3 is expressed at much lower level than isoform 1. There are three named isoforms.
  • Cellular localizationMembrane; Single-pass type I membrane protein.
  • Database links
  • Alternative names
    • 19A antibody
    • 19A24 protein antibody
    • CD 319 antibody
    • CD2 like receptor activating cytotoxic cells antibody
    • CD2 subset 1 antibody
    • CD319 antibody
    • CD319 antigen antibody
    • CRACC antibody
    • CS1 antibody
    • Membrane protein FOAP 12 antibody
    • Novel Ly9 antibody
    • Novel LY9 (lymphocyte antigen 9) like protein antibody
    • Protein 19A antibody
    • SLAM family member 7 antibody
    • SLAMF 7 antibody
    see all

Anti-SLAMF7 antibody [162] (Phycoerythrin) images

  • Staining of normal human peripheral blood cells with Anti-Human CD8a FITC and Mouse IgG2a ? Isotype Control PE (left) or ab95827 (right).
    Cells in the lymphocyte gate were used for analysis.

References for Anti-SLAMF7 antibody [162] (Phycoerythrin) (ab95827)

This product has been referenced in:
  • Tassi I & Colonna M The cytotoxicity receptor CRACC (CS-1) recruits EAT-2 and activates the PI3K and phospholipase Cgamma signaling pathways in human NK cells. J Immunol 175:7996-8002 (2005). Read more (PubMed: 16339536) »
  • Bouchon A  et al. Activation of NK cell-mediated cytotoxicity by a SAP-independent receptor of the CD2 family. J Immunol 167:5517-21 (2001). Read more (PubMed: 11698418) »

See all 2 Publications for this product

Product Wall

There are currently no Abreviews or Questions for ab95827.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"