Overview

  • Product nameAnti-Slap antibody
    See all Slap primary antibodies
  • Description
    Mouse monoclonal to Slap
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 1-277 of Human Slap

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityMonoclonal
  • IsotypeIgG2b
  • Light chain typekappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab58290 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionAdapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
    • Tissue specificityExpressed in lung and fetal brain. Weakly expressed in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas.
    • Sequence similaritiesContains 1 SH2 domain.
      Contains 1 SH3 domain.
    • DomainThe C-terminal domain is essential for the homodimerization and the interaction with CBL. While the interaction with CBL is apparently mediated via the hydrophobic region of this domain, the highly charged region is apparently required for the homodimerization.
    • Cellular localizationCytoplasm. Endosome. Colocalizes with endosomes.
    • Information by UniProt
    • Database links
    • Alternative names
      • hSLAP antibody
      • SLA 1 antibody
      • sla antibody
      • SLA1 antibody
      • SLAP 1 antibody
      • SLAP antibody
      • SLAP-1 antibody
      • SLAP1 antibody
      • SLAP1_HUMAN antibody
      • Src like adapter antibody
      • Src like adapter protein 1 antibody
      • Src like adaptor antibody
      • SRC-like-adapter antibody
      • Src-like-adapter protein 1 antibody
      see all

    Anti-Slap antibody images

    • Western blot against tagged recombinant protein immunogen using ab58290 Slap antibody at 1ug/ml. Predicted band size of immunogen is 56 kDa

    References for Anti-Slap antibody (ab58290)

    ab58290 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab58290.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"