Overview

  • Product nameAnti-Slap antibody
    See all Slap primary antibodies
  • Description
    Rabbit polyclonal to Slap
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Recombinant protein fragment containing a sequence corresponding to a region within amino acids 1-248 of Human Slap (AAH07042).

  • Positive control
    • 293T and A431 cell lysates

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: 0.01% Thimerosal (merthiolate)
    Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab96620 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 31 kDa.

Target

  • FunctionAdapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
  • Tissue specificityExpressed in lung and fetal brain. Weakly expressed in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas.
  • Sequence similaritiesContains 1 SH2 domain.
    Contains 1 SH3 domain.
  • DomainThe C-terminal domain is essential for the homodimerization and the interaction with CBL. While the interaction with CBL is apparently mediated via the hydrophobic region of this domain, the highly charged region is apparently required for the homodimerization.
  • Cellular localizationCytoplasm. Endosome. Colocalizes with endosomes.
  • Information by UniProt
  • Database links
  • Alternative names
    • hSLAP antibody
    • SLA 1 antibody
    • sla antibody
    • SLA1 antibody
    • SLAP 1 antibody
    • SLAP antibody
    • SLAP-1 antibody
    • SLAP1 antibody
    • SLAP1_HUMAN antibody
    • Src like adapter antibody
    • Src like adapter protein 1 antibody
    • Src like adaptor antibody
    • SRC-like-adapter antibody
    • Src-like-adapter protein 1 antibody
    see all

Anti-Slap antibody images

  • All lanes : Anti-Slap antibody (ab96620) at 1/2000 dilution

    Lane 1 : 293T whole cell lysate
    Lane 2 : A431 whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 31 kDa

References for Anti-Slap antibody (ab96620)

ab96620 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"