Anti-Sla antibody (ab96620)
Key features and details
- Rabbit polyclonal to Sla
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Sla antibody -
Description
Rabbit polyclonal to Sla -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Cow -
Immunogen
Recombinant fragment. This information is proprietary to Abcam and/or its suppliers.
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Positive control
- 293T and A431 cell lysates
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab96620 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/3000. Predicted molecular weight: 31 kDa.
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Notes |
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WB
1/500 - 1/3000. Predicted molecular weight: 31 kDa. |
Target
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Function
Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. -
Tissue specificity
Expressed in lung and fetal brain. Weakly expressed in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas. -
Sequence similarities
Contains 1 SH2 domain.
Contains 1 SH3 domain. -
Domain
The C-terminal domain is essential for the homodimerization and the interaction with CBL. While the interaction with CBL is apparently mediated via the hydrophobic region of this domain, the highly charged region is apparently required for the homodimerization. -
Cellular localization
Cytoplasm. Endosome. Colocalizes with endosomes. - Information by UniProt
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Database links
- Entrez Gene: 6503 Human
- Entrez Gene: 20491 Mouse
- Entrez Gene: 338477 Rat
- Omim: 601099 Human
- SwissProt: Q13239 Human
- SwissProt: Q60898 Mouse
- SwissProt: P59622 Rat
- Unigene: 75367 Human
see all -
Alternative names
- hSLAP antibody
- SLA 1 antibody
- sla antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab96620 has not yet been referenced specifically in any publications.