Overview

  • Product nameAnti-SLC12A3 antibody
    See all SLC12A3 primary antibodies
  • Description
    Rabbit polyclonal to SLC12A3
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 980-1029 (ALIVITLPIG RKGKCPSSLY MAWLETLSQD LRPPVILIRG NQENVLTFYC) of Human SLC12A3 (NP_000330).

  • Positive control
    • ACHN cell lysate

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab99097 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 114 kDa.Can be blocked with SLC12A3 peptide (ab203575). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionElectrically silent transporter system. Mediates sodium and chloride reabsorption.
  • Tissue specificityPredominant in kidney.
  • Involvement in diseaseDefects in SLC12A3 are the cause of Gitelman syndrome (GS) [MIM:263800]. GS is an autosomal recessive disorder characterized by hypokalemic alkalosis in combination with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. Patients are often asymptomatic or present transient periods of muscular weakness and tetany, usually accompanied by abdominal pain, vomiting and fever. The phenotype is highly heterogeneous in terms of age at onset and severity. Cardinal features such as hypocalciuria and hypomagnesemia might also change during the life cycle of a given patient. GS has overlapping features with Bartter syndrome.
  • Sequence similaritiesBelongs to the SLC12A transporter family.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ96318 antibody
    • Na Cl cotransporter antibody
    • Na Cl symporter antibody
    • Na-Cl symporter antibody
    • NaCl electroneutral thiazide sensitive cotransporter antibody
    • NCC antibody
    • NCCT antibody
    • S12A3_HUMAN antibody
    • slc12a3 antibody
    • Solute carrier family 12 (sodium/chloride transporters) member 3 antibody
    • Solute carrier family 12 member 3 antibody
    • Thiazide sensitive Na Cl cotransporter antibody
    • Thiazide sensitive sodium chloride cotransporter antibody
    • Thiazide-sensitive sodium-chloride cotransporter antibody
    • TSC antibody
    see all

Anti-SLC12A3 antibody images

  • Anti-SLC12A3 antibody (ab99097) at 1 µg/ml + ACHN cell lsyate at 10 µg

    Predicted band size : 114 kDa

References for Anti-SLC12A3 antibody (ab99097)

ab99097 has not yet been referenced specifically in any publications.

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