Overview

  • Product nameAnti-SLC12A4 antibody
    See all SLC12A4 primary antibodies
  • Description
    Mouse monoclonal to SLC12A4
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 1-110 of Human SLC12A4

Properties

Applications

Our Abpromise guarantee covers the use of ab58163 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionMediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity.
    • Tissue specificityUbiquitous. Levels are much higher in erythrocytes from patients with Hb SC and Hb SS compared to normal AA erythrocytes. This may contribute to red blood cell dehydration and to the manifestation of sickle cell disease by increasing the intracellular concentration of HbS. Isoform 1 was not detected in circulating reticulocytes.
    • Sequence similaritiesBelongs to the SLC12A transporter family.
    • Post-translational
      modifications
      N-glycosylated.
    • Cellular localizationMembrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • Electroneutral potassium chloride cotransporter 1 antibody
      • Electroneutral potassium-chloride cotransporter 1 antibody
      • Erythroid K Cl cotransporter 1 antibody
      • Erythroid K-Cl cotransporter 1 antibody
      • FLJ40489 antibody
      • hKCC 1 antibody
      • hKCC1 antibody
      • KCC 1 antibody
      • KCC1 antibody
      • Potassium transport protein antibody
      • Potassium/chloride cotransporter 1 antibody
      • S12A4_HUMAN antibody
      • Slc12a4 antibody
      • Solute carrier family 12 (potassium/chloride transporters) member 4 antibody
      • Solute carrier family 12 member 4 antibody
      see all

    Anti-SLC12A4 antibody images

    • Western blot against tagged recombinant protein immunogen using ab58163 SLC12A4 antibody at 1ug/ml. Predicted band size of immunogen is 35 kDa

    References for Anti-SLC12A4 antibody (ab58163)

    ab58163 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab58163.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"