Overview

  • Product nameAnti-SLC12A4 antibody
    See all SLC12A4 primary antibodies
  • Description
    Rabbit polyclonal to SLC12A4
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Sheep, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 1-50 (MPHFTVVPVD GPRRGDYDNL EGLSWVDYGE RAELDDSDGH GNHRESSPFL) of Human SLC12A4 (NP_005063).

  • Positive control
    • PANC1 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab99053 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 121 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionMediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity.
  • Tissue specificityUbiquitous. Levels are much higher in erythrocytes from patients with Hb SC and Hb SS compared to normal AA erythrocytes. This may contribute to red blood cell dehydration and to the manifestation of sickle cell disease by increasing the intracellular concentration of HbS. Isoform 1 was not detected in circulating reticulocytes.
  • Sequence similaritiesBelongs to the SLC12A transporter family.
  • Post-translational
    modifications
    N-glycosylated.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Electroneutral potassium chloride cotransporter 1 antibody
    • Electroneutral potassium-chloride cotransporter 1 antibody
    • Erythroid K Cl cotransporter 1 antibody
    • Erythroid K-Cl cotransporter 1 antibody
    • FLJ40489 antibody
    • hKCC 1 antibody
    • hKCC1 antibody
    • KCC 1 antibody
    • KCC1 antibody
    • Potassium transport protein antibody
    • Potassium/chloride cotransporter 1 antibody
    • S12A4_HUMAN antibody
    • Slc12a4 antibody
    • Solute carrier family 12 (potassium/chloride transporters) member 4 antibody
    • Solute carrier family 12 member 4 antibody
    see all

Anti-SLC12A4 antibody images

  • Anti-SLC12A4 antibody (ab99053) at 1 µg/ml + PANC1 cell lysate at 10 µg

    Predicted band size : 121 kDa

References for Anti-SLC12A4 antibody (ab99053)

ab99053 has not yet been referenced specifically in any publications.

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