Overview

  • Product name
  • Description
    Rabbit polyclonal to SLC12A4
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Sheep, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 1-50 (MPHFTVVPVD GPRRGDYDNL EGLSWVDYGE RAELDDSDGH GNHRESSPFL) of Human SLC12A4 (NP_005063).

  • Positive control
    • PANC1 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab99053 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 121 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Function
    Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity.
  • Tissue specificity
    Ubiquitous. Levels are much higher in erythrocytes from patients with Hb SC and Hb SS compared to normal AA erythrocytes. This may contribute to red blood cell dehydration and to the manifestation of sickle cell disease by increasing the intracellular concentration of HbS. Isoform 1 was not detected in circulating reticulocytes.
  • Sequence similarities
    Belongs to the SLC12A transporter family.
  • Post-translational
    modifications
    N-glycosylated.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Electroneutral potassium chloride cotransporter 1 antibody
    • Electroneutral potassium-chloride cotransporter 1 antibody
    • Erythroid K Cl cotransporter 1 antibody
    • Erythroid K-Cl cotransporter 1 antibody
    • FLJ40489 antibody
    • hKCC 1 antibody
    • hKCC1 antibody
    • KCC 1 antibody
    • KCC1 antibody
    • Potassium transport protein antibody
    • Potassium/chloride cotransporter 1 antibody
    • S12A4_HUMAN antibody
    • Slc12a4 antibody
    • Solute carrier family 12 (potassium/chloride transporters) member 4 antibody
    • Solute carrier family 12 member 4 antibody
    see all

Images

  • Anti-SLC12A4 antibody (ab99053) at 1 µg/ml + PANC1 cell lysate at 10 µg

    Predicted band size : 121 kDa

References

ab99053 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab99053.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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