Overview

  • Product name
  • Description
    Goat polyclonal to SLC12A6
  • Specificity
    ab77338 is expected to recognise all 6 reported isofoms (NP_598408.1; NP_005126.1; NP_001035959.1; NP_001035960.1; NP_001035961.1; NP_001035962.1).
  • Tested applications
    Suitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Orangutan
  • Immunogen

    Synthetic peptide:

    SRHIDVCSKTKE

    , corresponding to internal sequence amino acids 384-395 of Human SLC12A6 (NP_001035959.1; NP_001035960.1; NP_001035961.1; NP_001035962.1; NP_005126.1; NP_598408.1.)

  • Positive control
    • Human Heart and kidney lysates.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab77338 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab77338 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
WB
  • Application notes
    Peptide ELISA: Use at an assay dependent dilution. Antibody detection limit dilution 1/16,000.
    WB: Use at a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 128 kDa (predicted molecular weight: 128 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells.
    • Tissue specificity
      Highly expressed in heart, brain and kidney. Detected at lower levels in skeletal muscle, placenta, lung and pancreas. Detected in umbilical vein endothelial cells. Isoform 2 is more abundant in kidney. Isoform 5 is testis specific. Expressed in the proximal tubule of the kidney (at protein level).
    • Involvement in disease
      Agenesis of the corpus callosum, with peripheral neuropathy
    • Sequence similarities
      Belongs to the SLC12A transporter family.
    • Post-translational
      modifications
      N-glycosylated.
    • Cellular localization
      Basolateral cell membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • ACCPN antibody
      • Electroneutral potassium-chloride cotransporter 3 antibody
      • Furosemide sensitive KCl cotransporter 3 antibody
      • Gaxp antibody
      • K-Cl cotransporter 3 antibody
      • KCC 3 antibody
      • KCC 3A antibody
      • KCC 3B antibody
      • KCC3 A antibody
      • KCC3 antibody
      • KCC3 B antibody
      • KCC3A antibody
      • KCC3B antibody
      • Potassium chloride cotransporter 3 antibody
      • Potassium chloride cotransporter KCC3a S3 antibody
      • S12A6_HUMAN antibody
      • SLC12 A6 antibody
      • SLC12A 6 antibody
      • SLC12A6 antibody
      • Solute carrier family 12 (potassium/chloride transporters), member 6 antibody
      • Solute carrier family 12 member 6 antibody
      • Solute carrier family 12, member 6 antibody
      see all

    Anti-SLC12A6 antibody images

    • Anti-SLC12A6 antibody (ab77338) at 0.1 µg/ml + Human Heart lysate (in RIPA buffer) at 35 µg

      Predicted band size : 128 kDa
      Observed band size : 128 kDa

    References for Anti-SLC12A6 antibody (ab77338)

    ab77338 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab77338.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

    Sign up