Overview

  • Product nameAnti-SLC17A5 antibody
    See all SLC17A5 primary antibodies
  • Description
    Rabbit polyclonal to SLC17A5
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Sheep, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • Immunogen

    Synthetic peptide (Human)

  • Positive control
    • Human skeletal muscle tissue

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab69819 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 µg/ml. Detects a band of approximately 55 kDa (predicted molecular weight: 55 kDa).Can be blocked with Human SLC17A5 peptide (ab178604). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
IHC-P Use a concentration of 4 - 8 µg/ml.

Target

  • FunctionTransports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential-dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva.
  • Tissue specificityFound in fetal lung and small intestine, and at lower level in fetal skin and muscle. In the adult, detected in placenta, kidney and pancreas. Abundant in the endothelial cells of tumors from ovary, colon, breast and lung, but is not detected in endothelial cells from the corresponding normal tissues.
  • Involvement in diseaseSalla disease
    Infantile sialic acid storage disorder
  • Sequence similaritiesBelongs to the major facilitator superfamily. Sodium/anion cotransporter family.
  • Cellular localizationCell membrane. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Lysosome membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • AST antibody
    • H(+)/nitrate cotransporter antibody
    • H(+)/sialic acid cotransporter antibody
    • ISSD antibody
    • Membrane glycoprotein HP59 antibody
    • NSD antibody
    • S17A5_HUMAN antibody
    • SD antibody
    • Sialic acid storage disease antibody
    • Sialin antibody
    • SIASD antibody
    • Slc17a5 antibody
    • SLD antibody
    • Solute carrier family 17 (anion/sugar transportermember 5 antibody
    • Solute carrier family 17 member 5 antibody
    • Vesicular H(+)/Aspartate-glutamate cotransporter antibody
    see all

Anti-SLC17A5 antibody images

  • Anti-SLC17A5 antibody (ab69819) at 0.5 µg/ml + Transfected 293T cell lysate at 10 µg with 5% skim milk / PBS buffer

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 55 kDa
    Observed band size : 55 kDa
    Additional bands at : 23 kDa. We are unsure as to the identity of these extra bands.
  • Immunohistochemical analysis of paraffin embedded human muscle tissue labelled with ab69819 at 8 µg/ml. Positively labelled skeletal cells are indicated with arrows. Magnification 400X.

References for Anti-SLC17A5 antibody (ab69819)

ab69819 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting Abcam regarding ab69819.


The immunogen sequence is XXX.

I hope this information is helpful. Please do not hesitate to contact me if you have any additional questions.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"