Overview

  • Product name
    Anti-SLC19A3 antibody
  • Description
    Rabbit polyclonal to SLC19A3
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 225-255 of Human SLC19A3, conjugated to KLH.

  • Positive control
    • NIH-H292 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab103950 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 56 kDa.

Target

  • Relevance
    SLC19A3 is a member of the reduced folate family of micronutrient transporter genes. It is a ubiquitously expressed transmembrane thiamine transporter that lacks folate transport activity yet mediates high affinity thiamine uptake propably via a proton anti-port mechanism. Mutations in this gene cause biotin-responsive basal ganglia disease (BBGD); a recessive disorder manifested in childhood that progresses to chronic encephalopathy, dystonia, quadriparesis, and death if untreated. Patients with BBGD have bilateral necrosis in the head of the caudate nucleus and in the putamen. Mutations in this gene also cause a Wernicke's-like encephalopathy.
  • Cellular localization
    Plasma membrane
  • Database links
  • Alternative names
    • Solute carrier family 19 member 3 antibody
    • Thiamine transporter 2 antibody
    • thTr 2 antibody
    • THTR2 antibody

Images

  • Anti-SLC19A3 antibody (ab103950) at 1/100 dilution + NIH-H292 cell lysate at 35 µg

    Predicted band size : 56 kDa

References

This product has been referenced in:
  • Ghosal A  et al. Enterotoxigenic Escherichia coli infection and intestinal thiamin uptake: studies with intestinal epithelial Caco-2 monolayers. Am J Physiol Cell Physiol 305:C1185-91 (2013). Read more (PubMed: 24133060) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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