Anti-SLC22A1 antibody (ab123128)

Overview

• Product name
  Anti-SLC22A1 antibody
  See all SLC22A1 primary antibodies
• Description
  Rabbit polyclonal to SLC22A1
• Tested applications
  Suitable for: WBmore details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 510-539 of Human SLC22A1 (O15245, NP_003048.1, NP_694857.1).

• Positive control
  • HepG2 cell line lysates.

Properties

• Form
  Liquid
• Storage instructions
  Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
• Storage buffer
  Preservative: 0.09% Sodium azide
  Constituent: 99% PBS
• Concentration information loading...
• Purity
  Immunogen affinity purified
• Purification notes
  ab123128 is purified through a protein A column, followed by peptide affinity purification.
• Clonality
  Polyclonal
• Isotype
  IgG
• Research areas
  • Signal Transduction
  • Metabolism
  • Plasma Membrane
  • Channels

  • Metabolism
  • Types of disease
  • Cancer

Associated products

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

Applications

Target

• Function
  Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin-dependent kinase II and LCK tyrosine kinase.
• Tissue specificity
  Widely expressed with high level in liver. Isoform 1 and isoform 2 are expressed in liver. Isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in glial cell lines.
• Sequence similarities
  Belongs to the major facilitator superfamily. Organic cation transporter family.
• Post-translational
  modifications
  Phosphorylated.
• Cellular localization
  Basolateral cell membrane.

• Target information above from: UniProt accession O15245 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 6580 Human
  • Omim: 602607 Human
  • SwissProt: O15245 Human
  • SwissProt: O15395 Human
  • Unigene: 117367 Human
• Alternative names
  • hOCT1 antibody
  • OCT1 antibody
  • oct1_cds antibody

  • Organic cation transporter 1 antibody
  • S22A1_HUMAN antibody
  • Slc22a1 antibody
  • solute carrier family 22 (organic cation transporter), member 1 antibody
  • Solute carrier family 22 member 1 antibody

  see all

Protocols

• Western blot protocols