Overview

  • Product nameAnti-SLC22A1 antibody
    See all SLC22A1 primary antibodies
  • Description
    Rabbit polyclonal to SLC22A1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 510-539 of Human SLC22A1 (O15245, NP_003048.1, NP_694857.1).

  • Positive control
    • HepG2 cell line lysates.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage bufferPreservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesab123128 is purified through a protein A column, followed by peptide affinity purification.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab123128 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 61 kDa.

Target

  • FunctionTranslocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin-dependent kinase II and LCK tyrosine kinase.
  • Tissue specificityWidely expressed with high level in liver. Isoform 1 and isoform 2 are expressed in liver. Isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in glial cell lines.
  • Sequence similaritiesBelongs to the major facilitator superfamily. Organic cation transporter family.
  • Post-translational
    modifications
    Phosphorylated.
  • Cellular localizationBasolateral cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • hOCT1 antibody
    • OCT1 antibody
    • oct1_cds antibody
    • Organic cation transporter 1 antibody
    • S22A1_HUMAN antibody
    • Slc22a1 antibody
    • solute carrier family 22 (organic cation transporter), member 1 antibody
    • Solute carrier family 22 member 1 antibody
    see all

Anti-SLC22A1 antibody images

  • Anti-SLC22A1 antibody (ab123128) at 1/100 dilution + HepG2 cell line lysates at 35 µg

    Predicted band size : 61 kDa

References for Anti-SLC22A1 antibody (ab123128)

This product has been referenced in:
  • Hubeny A  et al. Expression of Organic Anion Transporting Polypeptide 1A2 in Red Blood Cells and Its Potential Impact on Antimalarial Therapy. Drug Metab Dispos 44:1562-8 (2016). Read more (PubMed: 27504015) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"