The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 0.5 µg/ml. Predicted molecular weight: 57 kDa.
Use a concentration of 2.5 - 20 µg/ml.
FunctionCell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis.
Tissue specificityExpressed in brain.
Sequence similaritiesBelongs to the major facilitator superfamily. Organic cation transporter family.
Cellular localizationCell membrane. Vacuole membrane. Upon LCN2-binding, it is internalized.
Potent brain type organic ion transporter antibody
Solute carrier family 22 member 17 antibody
Solute carrier family 22 organic cation transporter member 17 antibody
Anti-SLC22A17 antibody images
Western blot - Anti-SLC22A17 antibody (ab124506)
All lanes : Anti-SLC22A17 antibody (ab124506) at 1 µg/ml
Lane 1 : SK-N-SH cell lysate Lane 2 : SK-N-SH cell lysate with blocking peptide
Lysates/proteins at 15 µg per lane.
Predicted band size : 57 kDa
References for Anti-SLC22A17 antibody (ab124506)
This product has been referenced in:
Dekens DW et al. Neutrophil Gelatinase-Associated Lipocalin and its Receptors in Alzheimer's Disease (AD) Brain Regions: Differential Findings in AD with and without Depression. J Alzheimers Dis55:763-776 (2017).
Read more (PubMed: 27716662) »