Overview

  • Product name
  • Description
    Rabbit polyclonal to SLC22A17
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human SLC22A17 (C terminal).

  • Positive control
    • SK-N-SH cell lysate; Rat kidney tissue

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.02% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab124506 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 µg/ml. Predicted molecular weight: 57 kDa.
IHC-P Use a concentration of 2.5 - 20 µg/ml.

Target

  • Function
    Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis.
  • Tissue specificity
    Expressed in brain.
  • Sequence similarities
    Belongs to the major facilitator superfamily. Organic cation transporter family.
  • Cellular localization
    Cell membrane. Vacuole membrane. Upon LCN2-binding, it is internalized.
  • Information by UniProt
  • Database links
  • Alternative names
    • 24p3 receptor antibody
    • 24p3R antibody
    • BOCT antibody
    • BOIT antibody
    • Brain type organic cation transporter antibody
    • Brain-type organic cation transporter antibody
    • hBOIT antibody
    • Lipocalin-2 receptor antibody
    • Neutrophil gelatinase associated lipocalin receptor antibody
    • Neutrophil gelatinase-associated lipocalin receptor antibody
    • NGAL receptor antibody
    • NgalR antibody
    • NGALR2 antibody
    • NGALR3 antibody
    • OTTHUMP00000082690 antibody
    • OTTHUMP00000082691 antibody
    • Potent brain type organic ion transporter antibody
    • S22AH_HUMAN antibody
    • Slc22a17 antibody
    • Solute carrier family 22 member 17 antibody
    • Solute carrier family 22 organic cation transporter member 17 antibody
    see all

Images

  • All lanes : Anti-SLC22A17 antibody (ab124506) at 1 µg/ml

    Lane 1 : SK-N-SH cell lysate
    Lane 2 : SK-N-SH cell lysate with blocking peptide

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 57 kDa

References

This product has been referenced in:
  • Dekens DW  et al. Neutrophil Gelatinase-Associated Lipocalin and its Receptors in Alzheimer's Disease (AD) Brain Regions: Differential Findings in AD with and without Depression. J Alzheimers Dis 55:763-776 (2017). WB ; Human . Read more (PubMed: 27716662) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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