Overview

  • Product name
  • Description
    Rabbit polyclonal to SLC22A17
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Pig
  • Immunogen

    Synthetic peptide to a region within residues: CYQPVGGGGS PSDFYLCSLL ASGTAALACV FLGVTVDRFG RRGILLLSMT, corresponding to internal sequence amino acids 324-373 of Human SLC22A17 (NP_065105)

  • Positive control
    • DU145 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab90099 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 58 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Function
    Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis.
  • Tissue specificity
    Expressed in brain.
  • Sequence similarities
    Belongs to the major facilitator superfamily. Organic cation transporter family.
  • Cellular localization
    Cell membrane. Vacuole membrane. Upon LCN2-binding, it is internalized.
  • Information by UniProt
  • Database links
  • Alternative names
    • 24p3 receptor antibody
    • 24p3R antibody
    • BOCT antibody
    • BOIT antibody
    • Brain type organic cation transporter antibody
    • Brain-type organic cation transporter antibody
    • hBOIT antibody
    • Lipocalin-2 receptor antibody
    • Neutrophil gelatinase associated lipocalin receptor antibody
    • Neutrophil gelatinase-associated lipocalin receptor antibody
    • NGAL receptor antibody
    • NgalR antibody
    • NGALR2 antibody
    • NGALR3 antibody
    • OTTHUMP00000082690 antibody
    • OTTHUMP00000082691 antibody
    • Potent brain type organic ion transporter antibody
    • S22AH_HUMAN antibody
    • Slc22a17 antibody
    • Solute carrier family 22 member 17 antibody
    • Solute carrier family 22 organic cation transporter member 17 antibody
    see all

Images

  • Anti-SLC22A17 antibody (ab90099) at 1 µg/ml (in 5% skim milk / PBS buffer) + DU145 cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size: 58 kDa



    Gel concentration 12%

References

ab90099 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab90099.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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