Overview

  • Product name
  • Description
    Rabbit polyclonal to SLC22A4
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 521-550 of Human SLC22A4 (NP_003050.2).

  • Positive control
    • HeLa cell line lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab107727 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 62 kDa.

Target

  • Function
    Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET).
  • Tissue specificity
    Widely expressed. Highly expressed in whole blood, bone marrow, trachea and fetal liver. Weakly expressed in kidney, skeletal muscle, prostate, lung, pancreas, placenta, heart, uterus, spleen and spinal cord. Highly expressed in intestinal cell types affected by Crohn disease, including epithelial cells. Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells. Predominantly expressed in CD14 cells in peripheral blood mononuclear cells.
  • Involvement in disease
    Genetic variations in SLC22A4 are a cause of susceptibility to rheumatoid arthritis (RA) [MIM:180300]. It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.
  • Sequence similarities
    Belongs to the major facilitator superfamily. Organic cation transporter family.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Ergothioneine transporter antibody
    • ET transporter antibody
    • integral membrane transport protein antibody
    • LSTP Like 2 antibody
    • MGC34546 antibody
    • MGC40524 antibody
    • Octn1 antibody
    • Organic cation transporter 1 antibody
    • Organic cation/carnitine transporter 1 antibody
    • RP23-354D12.1 antibody
    • S22A4_HUMAN antibody
    • Slc22a4 antibody
    • Solute carrier family (organic cation transporter), member 4 antibody
    • solute carrier family 22 (organic cation/zwitterion transporter), member 4 antibody
    • Solute carrier family 22 member 4 antibody
    see all

Anti-SLC22A4 antibody images

  • Anti-SLC22A4 antibody (ab107727) at 1/100 dilution + HeLa cell line lysates at 35 µg

    Predicted band size : 62 kDa

References for Anti-SLC22A4 antibody (ab107727)

This product has been referenced in:
  • Li RW  et al. Uptake and protective effects of ergothioneine in human endothelial cells. J Pharmacol Exp Ther 350:691-700 (2014). Human . Read more (PubMed: 25022513) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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